Pizotifen CAS NO.15574-96-6
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017112
CAS NO.15574-96-6
Purity 98%
MDL NumberMFCD00864192
EINEC Molecular Formula C19H21NS
Molecular Weight 295.4417
Melting point: 147~152°C
| Aspect | Details |
|---|---|
| Chemical Structure | Pizotifen is a tricyclic compound with the molecular formula C₁₉H₂₁NS. It has a molecular weight of 295.4 g/mol. |
| Mechanism of Action | Pizotifen is a potent serotonin (5-HT) antagonist, primarily blocking 5-HT₂A and 5-HT₂C receptors. It also has weak antihistamine (H₁ receptor antagonist), anticholinergic, and bradykinin antagonist effects. These actions help reduce vasodilation and pain associated with migraines. |
| Clinical Uses | – Migraine Prevention: Reduces the frequency and severity of migraine attacks.<br>- Cluster Headaches: Occasionally used for prevention.<br>- Other Uses: May be used for chronic urticaria, erythromelalgia, and certain types of pain management. |
| Pharmacokinetics | – Absorption: Rapid, with an absorption half-life of 0.5–0.8 hours and a bioavailability of 78%.<br>- Distribution: Volume of distribution is 833 L in adults.<br>- Metabolism: Extensively metabolized in the liver, primarily via N-glucuronidation.<br>- Elimination: Elimination half-life is approximately 23 hours. |
| Side Effects | Common side effects include drowsiness, fatigue, increased appetite, weight gain, nausea, dizziness, and muscle pain. |
| Special Precautions | – Not recommended for patients with angle-closure glaucoma or prostate hypertrophy.<br>- Caution is advised for drivers and those operating machinery.<br>- Avoid concurrent use with monoamine oxidase inhibitors. |
| Storage Conditions | Store in a cool, dry place, protected from light |
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