Agrochemicals

Pivaloyl Chloride (CAS No. 3282-30-2) 

1. Basic Information

• Chemical Name: Pivaloyl chloride
• Synonyms: Trimethylacetyl chloride; 2,2-Dimethylpropanoyl chloride
• CAS Number: 3282-30-2
• Molecular Formula: C₅H₉ClO
• Molecular Weight: 120.58 g/mol
• Appearance: Colorless to pale yellow liquid
• Odor: Pungent, irritating odor (similar to acetic acid)
• Odor Threshold: <1 ppm

2. Physical and Chemical Properties

• Melting Point: -57°C (-71°F)
• Boiling Point: 105-106°C (221-223°F)
• Density: 0.979 g/cm³ at 25°C
• Refractive Index: 1.412 at 20°C
• Solubility:
  • Reacts violently with water/alcohols
  • Soluble in ether, benzene, chloroform
• Vapor Pressure: 28 mmHg at 20°C
• Flash Point: 12°C (54°F) – Highly Flammable

3. Chemical Structure

      CH₃
       |
CH₃-C-CO-Cl
       |
      CH₃

4. Hazards (GHS Classification)

• Flammability: Highly flammable liquid and vapor (H225)
• Health Hazards:
  • Causes severe skin burns (H314)
  • Causes serious eye damage (H318)
  • Harmful if inhaled (H332)
• Environmental Hazards: Toxic to aquatic life (H402)
• NFPA Rating: Health 3, Flammability 2, Reactivity 1

5. Storage and Handling

• Storage:
  • Store under nitrogen/argon in cool (<25°C), dry place
  • Keep away from moisture and oxidizers
• Handling:
  • Use PTFE/Viton gloves + face shield
  • Work in fume hood with >100 fpm airflow
  • Ground all equipment (static hazard)

6. Applications

• Pharmaceuticals: Protecting group in peptide synthesis
• Agrochemicals: Production of pesticides
• Polymer Industry: Modifier for specialty resins

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