Piroxicam
Chemical Additives 2025-03-02
Molecular Formula: C15H13N3O4S
Molecular Weight: 331.4
CAS No.: 36322-90-4
Names and Identifiers
| Name | piroxicam usp |
| Synonyms | PIROXICAM Pipoxicam piroxicam usp AURORA KA-6753 4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE 4-HYDROXY-2-METHYL-3-(PYRID-2-YL-CARBAMOYL)-2H-1,2-BENZOTHIAZINE 1,2-DIOXIDE 4-HYDROXY-2-METHYL-3-(PYRID-2-YL-CARBAMOYL)-2H-1,2-BENZOTHIAZINE 1,1-DIOXIDE 4-Hydroxy-2-Methyl-1,2-Benzothiazine-3-Carboxylic Acid Ethylester-1,1-Dioxide 4-hydroxy-2-methyl-n-2-pyridinyl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide 4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide 3,4-DIHYDRO-2-METHYL-4-OXO-N-2-PYRIDYL-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE (3R)-2-methyl-4-oxo-N-(pyridin-2-yl)-3,4-dihydro-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
| CAS | 36322-90-4 |
| EINECS | 252-974-3 |
| InChI | InChI=1/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20) |
| InChIKey | QYSPLQLAKJAUJT-UHFFFAOYSA-N |
36322-90-4 – Physico-chemical Properties
| Molecular Formula | C15H13N3O4S |
| Molar Mass | 331.35 |
| Density | 1.3664 (rough estimate) |
| Melting Point | 198-200°C |
| Boling Point | 568.5±60.0 °C at 760 mmHg |
| Water Solubility | Soluble in water, ethanol, chloroform, ethyl acetate. |
| Solubility | Almost insoluble in water, slightly soluble in ethanol or ether, easily soluble in chloroform, slightly soluble in acetone, soluble in acid. |
| Appearance | off-white to yellowish solid |
| Color | White to Light yellow |
| Maximum wavelength(λmax) | [‘358nm(H2O)(lit.)’] |
| Merck | 14,7506 |
| pKa | 6.3 (2:1 dioxane-water) |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to heat |
| Refractive Index | 1.6320 (estimate) |
| MDL | MFCD00057317 |
| Physical and Chemical Properties | Yellow needle-like crystals. Melting Point 198-200 °c. Soluble in alkali and pyridine, ethanol-soluble, insoluble in water. Odorless and tasteless. |
| Use | Strong non-steroidal anti-inflammatory analgesic |
36322-90-4 – Risk and Safety
| Risk Codes | R22 – Harmful if swallowed R25 – Toxic if swallowed |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. |
| UN IDs | UN 2811 |
| WGK Germany | 3 |
| RTECS | DL0705000 |
| HS Code | 29349990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 orally in mice: 360 mg/kg (Wiseman) |
36322-90-4 – Upstream Downstream Industry
| Raw Materials | 2-Aminopyridine Ethyl chloroacetate Sodium saccharine Ethyl Alcohol |
36322-90-4 – Introduction
Piroxicam is a non-selective COX inhibitor with an IC50 of 6 mM.
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