Piribedil dihydrochloride
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80071758
CAS NO.78213-63-5
Purity 98%
MDL NumberMFCD09971034
Molecular FormulaC16H18N4O2.2HCl
Molecular Weight371.2616
| Item | Information |
|---|---|
| Mechanism of Action | Piribedil dihydrochloride is a potent dopamine D2 and D3 receptor agonist and an α2-adrenoceptor antagonist. It also inhibits MLL1 methyltransferase activity, which is involved in epigenetic regulation. |
| Indications | – Used for the treatment of Parkinson’s disease, particularly in patients with predominant tremor.<br>- Investigated for its potential in treating circulatory disorders and certain cancers. |
| Dosage Forms | Available as tablets (e.g., 50 mg) for oral administration. |
| Common Dosage | – Initial dose: 50 mg three times daily, increased gradually to a maintenance dose of 150-250 mg daily, divided into 3-4 doses.<br>- For combination with levodopa: Start with 50 mg daily, gradually increased to a maintenance dose of 50-150 mg daily. |
| Common Side Effects | – Gastrointestinal disturbances (nausea, vomiting, bloating).<br>- Orthostatic hypotension.<br>- Sedation, anxiety, agitation. |
| Serious Side Effects | – Sudden sleep onset.<br>- Cardiac arrhythmias.<br>- Hypotension. |
| Drug Interactions | – Antagonized by dopamine antagonists (e.g., phenothiazines, butyrophenones).<br>- Contraindicated with MAO inhibitors, sympathomimetics, and adrenergic drugs. |
| Contraindications | – Hypersensitivity to piribedil.<br>- Acute myocardial infarction.<br>- Pregnancy and breastfeeding. |
| Special Precautions | – Monitor for sudden sleep onset, especially in patients with Parkinson’s disease.<br>- Use with caution in patients with cardiovascular diseases.<br>- Gradually reduce the dose if discontinuing treatment. |
| Storage Conditions | Store at room temperature, protected from moisture |
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