Pireraquine tetraphosphate tetrahydrate CAS NO.4085-31-8
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017089
CAS NO.4085-31-8
Purity 97%
MDL NumberMFCD11870901
EINEC Molecular Formula C29H32Cl2N6.4H3Po4.4H2O
Molecular Weight 999.5524
| Aspect | Details |
|---|---|
| Chemical Structure | – IUPAC Name: 7-Chloro-4-propyl]piperazin-1-yl]quinoline; phosphoric acid; tetrahydrate <br>- Molecular Formula: C₂₉H₃₂Cl₂N₆·4H₃PO₄·4H₂O <br>- Molecular Weight: 999.60 |
| Mechanism of Action | – Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent that is highly active against chloroquine-resistant Plasmodium falciparum and Plasmodium vivax.<br>- It is effective in reducing parasitemia and has been used in combination with artemisinin for enhanced antimalarial activity. |
| Clinical Uses | – Used in antimalarial research and treatment, particularly against chloroquine-resistant strains of malaria.<br>- Investigated for its potential in combination therapy with other antimalarial agents. |
| Pharmacokinetics | – In animal studies, piperaquine (90 mg/kg, single i.p. injection) exhibited a half-life of 17.8 days, an AUC of 33.5 mg·h/L, an apparent clearance of 1.55 L/h/kg, and an apparent volume of distribution of 956 L/kg in healthy mice.<br>- In malaria-infected mice, the half-life was 16.1 days, AUC was 27.3 mg·h/L, clearance was 1.9 L/h/kg, and volume of distribution was 1,059 L/kg. |
| Physical Properties | – Appearance: White to off-white solid.<br>- Melting Point: 252°C (decomposition).<br>- Solubility: 6 mg/mL in water (ultrasonic assistance required); insoluble or slightly soluble in DMSO. |
| Storage Conditions | – Store at 4°C, sealed and protected from moisture.<br>- In solvent: -80°C for 6 months; -20°C for 1 month (sealed, protected from moisture). |
| Side Effects | – Information on side effects is limited, but as an antimalarial agent, it may cause gastrointestinal disturbances or other adverse effects seen with similar drugs. |
| Research Applications | – Used in studies related to antimalarial drug resistance and combination therapies.<br>- Investigated for its potential as an autophagy inhibitor. |
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