Active Pharmaceutical Ingredients

Catalog ID80017089

CAS NO.4085-31-8

Purity 97%

MDL NumberMFCD11870901

EINEC Molecular Formula C29H32Cl2N6.4H3Po4.4H2O

Molecular Weight 999.5524

Aspect	Details
Chemical Structure	– IUPAC Name: 7-Chloro-4-$4-\text{[}3-\text{[}4-(7-chloroquinolin-4-yl)piperazin-1-yl$propyl]piperazin-1-yl]quinoline; phosphoric acid; tetrahydrate <br>- Molecular Formula: C₂₉H₃₂Cl₂N₆·4H₃PO₄·4H₂O <br>- Molecular Weight: 999.60
Mechanism of Action	– Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent that is highly active against chloroquine-resistant Plasmodium falciparum and Plasmodium vivax.<br>- It is effective in reducing parasitemia and has been used in combination with artemisinin for enhanced antimalarial activity.
Clinical Uses	– Used in antimalarial research and treatment, particularly against chloroquine-resistant strains of malaria.<br>- Investigated for its potential in combination therapy with other antimalarial agents.
Pharmacokinetics	– In animal studies, piperaquine (90 mg/kg, single i.p. injection) exhibited a half-life of 17.8 days, an AUC of 33.5 mg·h/L, an apparent clearance of 1.55 L/h/kg, and an apparent volume of distribution of 956 L/kg in healthy mice.<br>- In malaria-infected mice, the half-life was 16.1 days, AUC was 27.3 mg·h/L, clearance was 1.9 L/h/kg, and volume of distribution was 1,059 L/kg.
Physical Properties	– Appearance: White to off-white solid.<br>- Melting Point: 252°C (decomposition).<br>- Solubility: 6 mg/mL in water (ultrasonic assistance required); insoluble or slightly soluble in DMSO.
Storage Conditions	– Store at 4°C, sealed and protected from moisture.<br>- In solvent: -80°C for 6 months; -20°C for 1 month (sealed, protected from moisture).
Side Effects	– Information on side effects is limited, but as an antimalarial agent, it may cause gastrointestinal disturbances or other adverse effects seen with similar drugs.
Research Applications	– Used in studies related to antimalarial drug resistance and combination therapies.<br>- Investigated for its potential as an autophagy inhibitor.

Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.

If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.