Piperacillin sodium
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017977
CAS NO.59703-84-3
Purity 98%
MDL NumberMFCD00917471
EINEC261-868-6
Molecular FormulaC23H26N5NaO7S
Molecular Weight539.5366
Melting point: 183~185°C
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C23H26N5NaO7S<br> Molecular weight: 539.54 g/mol |
| Physical Properties | Appearance: White to almost white crystalline powder<br> Melting point: 183–185°C (decomposition)<br> Solubility: Soluble in water (50 mg/mL), ethanol, and methanol |
| Mechanism of Action | Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death. Stable against certain β-lactamases but susceptible to extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases. Often combined with tazobactam to enhance activity. |
| Therapeutic Uses | Used for treating infections caused by susceptible strains of Gram-negative and Gram-positive bacteria, including Pseudomonas aeruginosa, Enterobacteriaceae, and anaerobic pathogens. Commonly used for lower respiratory tract, urinary tract, intra-abdominal, skin, and bloodstream infections. |
| Pharmacokinetics | Administered intravenously or intramuscularly. Widely distributed in body fluids and tissues. Primarily excreted via glomerular filtration. |
| Storage Conditions | Store in an inert atmosphere at 2–8°C. |
| Safety Information | Side Effects: Gastrointestinal disturbances, hypersensitivity reactions, potential alterations in blood cell counts.<br> Contraindications: Avoid in patients with hypersensitivity to piperacillin.<br> Drug Interactions: Monitor electrolyte levels when used with aminoglycosides. |
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