Pinacidil monohydrate
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80019602
CAS NO.85371-64-8
Purity 98%
MDL NumberMFCD00242745
Molecular Formula C13H19N5.H2O
Molecular Weight 263.3387
Melting point: 164~165°C
| Category | Information |
|---|---|
| Chemical Properties | – Molecular Formula: C₁₃H₂₁N₅O<br>- Molecular Weight: 263.34 g/mol |
| Mechanism of Action | – Potassium Channel Activation: Pinacidil monohydrate is a potassium channel activator that opens ATP-modulated potassium channels in vascular smooth muscle cells. This leads to hyperpolarization of the cell membrane, reducing intracellular calcium levels and causing vasodilation.<br>- Vasodilation: It reduces peripheral vascular resistance and lowers blood pressure without significant effects on cardiac electrophysiology. |
| Clinical Uses | – Antihypertensive: Used for the management of essential hypertension.<br>- Cardiovascular Research: Investigated for its potential in treating secondary renal hypertension and other cardiovascular conditions. |
| Physical Properties | – Appearance: White to off-white solid.<br>- Melting Point: 164-165°C.<br>- Solubility: Soluble in DMSO (97 mg/mL, 368.35 mM; sonication recommended) and ethanol (47 mg/mL, 178.48 mM; sonication recommended); insoluble in water. |
| Storage Conditions | – Powder: Store at -20°C for up to 3 years.<br>- In Solvent: Store at -80°C for up to 1 year. |
| Adverse Effects | – Common side effects include headache, edema, palpitations, and tachycardia.<br>- These effects are usually mild and transient but may occasionally be severe. |
| Synonyms | – Pinacidil hydrate.<br>- Pindac. |
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