Active Pharmaceutical Ingredients

Catalog ID80017792

CAS NO.630-93-3

Purity 96%

MDL NumberMFCD00069674

olecular formula C15H11N2O2Na

Molecular weight 274.2498

Aspect	Details
Mechanism of Action	Phenytoin sodium is a hydantoin derivative that acts as a voltage-gated sodium channel blocker. It stabilizes the inactive state of sodium channels, prolonging the neuronal refractory period and preventing the spread of seizure activity.
Storage Conditions	Store at room temperature (15° to 30°C). Protect from light and moisture.
Special Considerations	– Pregnancy: Phenytoin can cause teratogenic effects and fetal hydantoin syndrome. Women of childbearing potential should use effective contraception.<br>- Monitoring: Regular blood tests are required to monitor for hematologic, hepatic, and other adverse effects. Therapeutic drug monitoring is essential due to its narrow therapeutic index.<br>- Adverse Effects: Potential side effects include rash, gingival hyperplasia, Stevens-Johnson syndrome, and cardiovascular effects (e.g., hypotension, arrhythmias) with rapid intravenous administration.<br>- Drug Interactions: Phenytoin is metabolized by the hepatic P450 enzyme system and can interact with many drugs, including those that induce or inhibit CYP2C9 and CYP2C19.<br>- Discontinuation: Do not abruptly discontinue therapy, as it may lead to seizure recurrence.<br>- Behavioral Effects: May cause agitation, irritability, or suicidal thoughts. Patients should be monitored for changes in mood or behavior

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