Active Pharmaceutical Ingredients

Benzathine benzylpenicillin is an antibiotic medicine used to control streptococcal infection and prevent rheumatic fever, suitable for mild or moderate infections caused by bacteria sensitive to penicillin, such as pneumonia, scarlet fever, tonsillitis, otitis media, gonorrhea, etc. Lecithin as emulsifier applied to Penicillin G Benzathin can achieve good needle aspiration effect.

Description

Penicillin G Benzathin Plus 1% Lecithin is a white, odorless, crystalline powder.

Application

Penicillin antibiotics, used for mild or moderate infections caused by penicillin-sensitive bacteria, such as pneumonia, scarlet fever, tonsillitis, otitis media, gonorrhea, etc. It is mainly used to prevent rheumatic fever, treat syphilis in different stages, and control the prevalence of streptococcal infection.

Lecithin as emulsifier applied to Penicillin G Benzathin can achieve good needle aspiration effect.

Packing

5kg/bag or as customer’s requirements.

Storage

Protected from light. If the substance is sterile, store in a sterile, airtight, tamper- proof container.

Minimum Order

One package

Penicillin G Benzathin: A Veterinary Antibiotic

Penicillin G Benzathin is an important antibiotic in veterinary medicine, used for treating specific bacterial infections in animals.

1. General Characteristics

Aspect	Details
Classification	Beta – lactam antibiotic, specifically a penicillin. It is a long – acting form of penicillin G.
Source	Prepared by combining penicillin G with benzathine. Penicillin G is produced by the fermentation of Penicillium chrysogenum, and the benzathine salt is formed through chemical reactions to modify its pharmacokinetic properties.
Formulation	Usually available as an injectable suspension. The suspension form helps to slow the release of penicillin G from the injection site, providing a long – lasting antibacterial effect.
Solubility	Sparingly soluble in water. This property contributes to its slow – release characteristics. In the body, the benzathine portion gradually dissociates, releasing penicillin G over an extended period.

2. Mechanism of Action

Action	Explanation
Inhibition of Cell Wall Synthesis	Penicillin G Benzathin, like other penicillins, inhibits the synthesis of the bacterial cell wall. It binds to and inactivates penicillin – binding proteins (PBPs) in bacteria. These proteins are involved in the cross – linking of peptidoglycan chains, which is a crucial step in the formation of the rigid bacterial cell wall. By blocking this cross – linking process, the cell wall becomes weakened. As the bacteria grow and divide, the weakened cell wall cannot withstand the internal osmotic pressure, leading to cell lysis and death.
Selective Activity	It has a mainly Gram – positive antibacterial spectrum. It is highly effective against bacteria such as Staphylococcus spp., Streptococcus spp., and Clostridium spp. Some Gram – negative cocci, like Neisseria spp., are also sensitive to penicillin G benzathin. However, many Gram – negative bacilli are resistant due to the presence of outer membranes that prevent the penetration of the drug.

3. Clinical Applications and Considerations

Category	Details
Applications	– Treating respiratory tract infections in livestock and poultry. In cattle, it can be used to combat Streptococcus spp. infections that cause pneumonia. In poultry, it may be used against certain streptococcal and staphylococcal respiratory infections. – Managing skin and soft – tissue infections in animals. It is effective against Staphylococcus spp. and Streptococcus spp. that cause abscesses, cellulitis, and wound infections in dogs, cats, and livestock. – Treating some infections in horses, such as streptococcal infections in the upper respiratory tract or skin.
Considerations	– Overuse can contribute to the development of antibiotic – resistant bacteria. Adhering to proper dosage and treatment duration as prescribed by veterinarians is crucial. – Allergic reactions can occur in some animals, similar to human allergic reactions to penicillin. Symptoms may include rash, itching, swelling, and in severe cases, anaphylaxis. Monitoring for allergic reactions after administration is important. – Due to its slow – release nature, the onset of action may be slower compared to other forms of penicillin. It is not suitable for treating acute, life – threatening infections where rapid drug action is required. – Caution is needed when using it in combination with other drugs. There may be potential drug – drug interactions, especially with other antibiotics that target cell wall synthesis or drugs that affect the immune system.

Penicillin G Benzathin plays a significant role in maintaining the health of livestock, poultry, and companion animals by effectively treating certain bacterial infections with its long – acting properties.

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