Pemetrexed disodium CAS NO.150399-23-8
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017208
CAS NO.150399-23-8
Purity 98%
MDL NumberMFCD07779402
olecular formulaC20H19N5Na2O6
Molecular weight 471.3743
Melting point: 270~280°C
| Aspect | Details |
|---|---|
| Chemical Properties | – Molecular Formula: C20H19N5Na2O6<br>- Molecular Weight: 427.41 g/mol<br>- CAS Number: 150399-23-8<br>- Physical Appearance: White to almost white solid |
| Mechanism of Action | Pemetrexed is an antifolate that inhibits folate-dependent enzymes such as thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). These enzymes are crucial for DNA synthesis and repair, leading to antineoplastic activity. |
| Indications | – Treatment of malignant pleural mesothelioma in combination with cisplatin.<br>- Monotherapy for locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy. |
| Pharmacokinetics | – Absorption: Systemic exposure (AUC) and maximum plasma concentration (Cmax) increase proportionally with dose.<br>- Distribution: Steady-state volume of distribution is 16.1 liters.<br>- Protein Binding: 81% bound to plasma proteins.<br>- Metabolism: Not significantly metabolized by the liver.<br>- Excretion: Primarily eliminated in urine, with 70-90% of the dose recovered unchanged within 24 hours.<br>- Half-Life: 3.5 hours in patients with normal renal function.<br>- Clearance: 91.8 mL/min in patients with normal renal function. |
| Adverse Effects | – Common: Nausea, vomiting, fatigue, rash, diarrhea.<br>- Serious: Myelosuppression, pneumonitis. |
| Contraindications | Hypersensitivity to pemetrexed or any of its components. |
| Special Considerations | – Monitor renal function and blood counts regularly.<br>- Use with caution in patients with renal impairment.<br>- Folic acid and vitamin B12 supplementation are recommended to reduce toxicity. |
| Storage Conditions | Store in a cool, dry place, protected from light and moisture |
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