Pazopanib
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80071756
CAS NO.444731-52-6
Purity 99%
MDL NumberMFCD11616589
Molecular FormulaC21H23N7O2S
Molecular Weight437.526
| Category | Content |
|---|---|
| Generic Name | Pazopanib |
| Brand Name | Votrient |
| Chemical Formula | C21H23N2O3S·HCl |
| CAS Number | 386580-66-8 |
| Mechanism of Action | Pazopanib is a multi-tyrosine kinase inhibitor targeting VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-α, PDGFR-β, FGFR-1, FGFR-3, Kit, and other kinases. It inhibits angiogenesis and tumor growth. |
| Indications | – Treatment of advanced renal cell carcinoma.<br>- Treatment of advanced soft tissue sarcoma. |
| Dosage Forms | Tablets (200 mg) |
| Administration | – Usual dose: 800 mg once daily.<br>- Take at least 1 hour before or 2 hours after a meal. |
| Common Side Effects | – Fatigue, diarrhea, nausea, hypertension, hair color changes, weight loss. |
| Serious Side Effects | – Hepatotoxicity.<br>- QT prolongation.<br>- Cardiac dysfunction.<br>- Hemorrhagic events.<br>- Arterial and venous thrombotic events.<br>- Gastrointestinal perforation and fistula.<br>- Reversible Posterior Leukoencephalopathy Syndrome (RPLS). |
| Precautions | – Monitor hepatic function.<br>- Avoid strong CYP3A4 inhibitors.<br>- Use with caution in patients with cardiac or liver impairment.<br>- Not recommended during pregnancy. |
| Storage | Store at room temperature, protect from moisture. |
| Developer | GlaxoSmithKline |
| Approval Date | FDA approval in October 2009. |
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