Paxlovid
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
English Synonyms Nirmatrelvir PF-07321332 (1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
Catalog ID101225
CAS NO.2628280-40-8
Purity 95%
MDL NumberMFCD34473213
EINEC Molecular FormulaC23H32F3N5O4
Molecular Weight499.531
| Category | Content |
|---|---|
| Generic Name | Paxlovid (Nirmatrelvir/Ritonavir) |
| Brand Name | Paxlovid |
| Drug Class | Antiviral (Protease Inhibitor Combination) |
| Mechanism of Action | Paxlovid is a combination of nirmatrelvir and ritonavir. Nirmatrelvir is a reversible covalent peptidomimetic inhibitor of the main protease (Mpro) of SARS-CoV-2, which is crucial for viral replication. Ritonavir acts as a pharmacokinetic enhancer by inhibiting the cytochrome CYP3A4 enzyme, thereby increasing the half-life and bioavailability of nirmatrelvir. |
| Indications | Treatment of mild-to-moderate COVID-19 in adults who are at high risk for progression to severe disease, within 5 days of symptom onset. |
| Dosage Forms | Tablet (Nirmatrelvir 150 mg, Ritonavir 100 mg) |
| Administration | Oral, twice daily for 5 days. |
| Side Effects | Common side effects include altered taste, diarrhea, and hypertension. |
| Developer | Pfizer |
| Approval Date | Emergency use authorization granted in 2021 |
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