Active Pharmaceutical Ingredients

Catalog ID80017134

CAS NO.138786-67-1

Purity 98%

MDL NumberMFCD01658543

EINEC Molecular Formula C16H14F2N3NaO4S

Molecular Weight 405.3516

Aspect	Details
Mechanism of Action	Pantoprazole sodium is a proton pump inhibitor (PPI) that irreversibly binds to the (H+, K+)-ATPase enzyme system on the secretory surface of gastric parietal cells. This binding inhibits both basal and stimulated gastric acid secretion, regardless of the stimulus.
Clinical Uses	It is used for the short-term treatment of various gastrointestinal conditions, including duodenal ulcers, gastric ulcers, gastroesophageal reflux disease (GERD), and pathological hypersecretory conditions such as Zollinger-Ellison syndrome. It is also used to prevent gastrointestinal lesions induced by nonsteroidal anti-inflammatory drugs (NSAIDs) and to manage ulcers associated with Helicobacter pylori infection.
Storage Conditions	– Pantoprazole sodium 4 mg/mL stored in glass vials is stable for 3 days at room temperature (20°C to 25°C) with exposure to light.<br>- When stored in polypropylene syringes under refrigeration (2°C to 8°C) with protection from light, it is stable for 28 days.<br>- Diluted to 0.4 mg/mL in 5% dextrose in water (D5W) and stored in PVC minibags, it is stable for 2 days at room temperature or 14 days under refrigeration.<br>- At 0.8 mg/mL in D5W, it is stable for 3 days at room temperature or 28 days under refrigeration.<br>- Diluted to 0.4 or 0.8 mg/mL in 0.9% sodium chloride (NS) and stored in PVC minibags, it is stable for 3 days at room temperature or 28 days under refrigeration.
Special Precautions	– Do not use concurrently with medicines containing rilpivirine (e.g., Complera®, Edurant®, Odefsey®) to avoid adverse effects.<br>- Monitor for signs of acute tubulointerstitial nephritis, such as changes in urination frequency, blood in urine, fever, joint pain, nausea, or unusual fatigue.<br>- Long-term use may lead to vitamin B12 deficiency, increased risk of fractures, hypomagnesemia, and fundic gland polyps.<br>- Serious skin reactions and systemic lupus erythematosus may occur; monitor for joint pain, skin rash, or other symptoms.<br>- Do not stop taking pantoprazole without consulting a doctor.
Side Effects	Common side effects include headache, dizziness, nausea, and diarrhea. Serious side effects may include severe stomach pain, watery diarrhea, fever, seizures, irregular heartbeat, and skin reactions such as Stevens-Johnson syndrome

Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.

If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.