Palonosetron hydrochloride CAS NO.135729-62-3
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017071
CAS NO.135729-62-3
Purity 98%
MDL NumberMFCD07370072
EINEC Molecular FormulaC19H24N2O.HCl
Molecular Weight332.8676
| Aspect | Details |
|---|---|
| Chemical Structure | – Molecular Formula: C₁₉H₂₄N₂O·HCl<br>- Molecular Weight: 332.87 |
| Mechanism of Action | Palonosetron is a selective 5-HT₃ receptor antagonist. It blocks the 5-HT₃ receptors in the central nervous system and gastrointestinal tract, reducing nausea and vomiting caused by chemotherapy, surgery, or anesthesia. |
| Clinical Uses | – Prevention of chemotherapy-induced nausea and vomiting (CINV).<br>- Prevention of postoperative nausea and vomiting (PONV).<br>- Available as an injectable solution for intravenous administration. |
| Pharmacokinetics | – Renal Impairment: No significant effect on pharmacokinetics; no dose adjustment needed.<br>- Hepatic Impairment: No significant effect on clearance; no dose adjustment needed.<br>- Geriatric Use: No overall differences in safety or effectiveness observed in patients ≥65 years. |
| Side Effects | – Common: Headache, constipation.<br>- Serious: Severe allergic reactions (e.g., difficulty breathing, swelling of face/throat, hives), heart rhythm changes (e.g., QT prolongation), serotonin syndrome (e.g., agitation, fast heartbeat, muscle twitching). |
| Storage Conditions | Stored and administered by healthcare providers. |
| Overdose Management | No known antidote; supportive care recommended. Due to its large volume of distribution, dialysis is unlikely to be effective. |
| Physical Properties | – Appearance: White to off-white crystalline powder.<br>- Solubility: Freely soluble in water, soluble in methanol. |
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