Paliperidone
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80020153
CAS NO.144598-75-4
Purity 98%
MDL NumberMFCD00871802
Molecular Formula C23H27FN4O3
Molecular Weight 426.48
Melting point: 181~186°C
| Category | Information |
|---|---|
| Chemical Properties | – Molecular Formula: C₂₃H₂₇FN₄O₃<br>- Molecular Weight: 426.5 g/mol |
| Mechanism of Action | – Paliperidone is an atypical antipsychotic drug and the active metabolite of risperidone.<br>- It acts as a selective monoamine receptor antagonist, primarily targeting dopamine D₂ and serotonin 5-HT₂A receptors. |
| Clinical Uses | – Schizophrenia: Used for the treatment of schizophrenia in adults.<br>- Schizoaffective Disorder: Also indicated for schizoaffective disorder.<br>- Long-Acting Injectable Formulations: Available as paliperidone palmitate (PDP) for monthly or quarterly injections.<br>- Other Indications: Investigated for use in bipolar I disorder. |
| Dosage Forms | – Oral Tablets: Extended-release tablets available in various strengths (e.g., 1.5 mg, 3 mg, 6 mg, 9 mg, 12 mg).<br>- Injectable Suspensions: Long-acting injectable formulations (e.g., PDP) for intramuscular or subcutaneous use. |
| Side Effects | – Common side effects include headache, dizziness, sedation, weight gain, and injection-site pain.<br>- Other potential side effects: nausea, extremity pain, and elevated BMI.<br>- Serious side effects: akathisia, parkinsonism, and liver toxicity. |
| Storage Conditions | Store at room temperature, protect from light and moisture. |
| Special Notes | – Long-Acting Injectable Formulations: PDP has a long half-life (25-49 days for monthly injections; 2-4 months for quarterly injections).<br>- Safety Considerations: Increased mortality risk in elderly patients with dementia-related psychosis.<br>- Contraindications: Pregnancy, due to the risk of birth defects |
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