Active Pharmaceutical Ingredients

CAS NO.: 33069-62-4

Molecular formula: C47H51NO14

Molecular weight: 853.92

Standard: USP35

Content: ≥99%

Packaging: 5kg/tin

Paclitaxel: A Comprehensive Introduction

Paclitaxel, a well – known chemotherapeutic agent, has significantly impacted cancer treatment.

1. General Information

Aspect	Details
Synonym	Taxol
Source	Originally isolated from the bark of the Pacific yew tree (Taxus brevifolia)
Chemical Class	Taxane

2. Mechanism of Action

Action	Explanation
Microtubule Interaction	Binds to β – tubulin, promoting microtubule assembly and inhibiting disassembly. This leads to the formation of stable, non – functional microtubule bundles.
Cell Cycle Arrest	Causes cell cycle arrest in the G2/M phase, halting cancer cell division.
Apoptosis Induction	Prolonged cell cycle arrest triggers apoptosis, killing cancer cells.

3. Clinical Applications

Cancer Type	Treatment Role
Breast Cancer	Standard treatment, used in early – stage and metastatic cases, often in combination with other drugs.
Ovarian Cancer	Key drug in ovarian cancer treatment, improving patient survival.
Lung Cancer	Effective in non – small cell lung cancer, used as monotherapy or in combination.

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