p-Toluenesulfonyl Isocyanate
Pharmaceutical Materials 2025-03-02
CAS Number: 4083-64-1.
Molecular Formula: C8H7NO3S.
Molecular Weight: 197.21 g/mol.
Appearance: Colorless transparent liquid.
Usage: Commonly used as a dehydrating agent in chemical products and as an intermediate in the synthesis of pharmaceuticals or pesticides.
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
| Property | Details |
|---|---|
| Molecular Formula | C8H7NO3S |
| Molecular Weight | 197.21 g/mol |
| CAS Number | 4083-64-1 |
| Appearance | Colorless to pale yellow liquid or crystalline solid |
| Purity | Typically ≥98% |
| Melting Point | 38-40 °C (solid form) |
| Boiling Point | 120-125 °C (at 10 mmHg) |
| Density | ~1.2 g/cm³ (predicted) |
| Solubility | Soluble in organic solvents such as ether, benzene, and DMSO; reacts with water |
| Applications | Organic synthesis, pharmaceuticals, and chemical intermediates |
| Safety Considerations | Highly reactive and toxic; handle with care; avoid contact with skin, eyes, and moisture; store in a cool, dry place under inert gas |
| Suppliers | Available from specialized chemical suppliers globally |
Applications
p-Toluenesulfonyl Isocyanate is a reactive compound widely used in organic synthesis, pharmaceuticals, and as a chemical intermediate. Its isocyanate group and tosyl (p-toluenesulfonyl) moiety provide unique reactivity, making it a valuable tool in the synthesis of various chemicals.
In organic synthesis, p-Toluenesulfonyl Isocyanate is utilized as a building block for the synthesis of complex molecules, such as ureas, carbamates, and heterocyclic compounds. Its isocyanate group readily reacts with amines, alcohols, and other nucleophiles, allowing for the formation of stable bonds and the introduction of diverse chemical groups.
In pharmaceuticals, this compound is used in the development of drugs with diverse biological activities. The tosyl group can be used as a protecting group or as a means to introduce specific functionality into drug molecules.
As a chemical intermediate, p-Toluenesulfonyl Isocyanate is employed in the synthesis of various organic compounds, including pesticides, dyes, and polymers. Its reactivity with water and other protic solvents necessitates careful handling and storage under inert gas to maintain its stability and reactivity.
