P-fluorotoluene
Agrochemicals 2025-03-02
Application of p-Fluorotoluene
p-Fluorotoluene is an important raw material for organic fluorine compounds, widely used in the synthesis of:
- Pharmaceutical intermediates
- Pesticide intermediates
- Dyes
- Polymer fluorine plastic intermediates
- Fluorine-containing aromatic derivatives
Production Methods
Currently, p-fluorotoluene is produced via indirect methods, with key fluorination processes including:
- Diazotization Fluorination (Hiemann Reaction)
- Traditional method using p-toluidine diazotization.
- Modified approaches (e.g., diazotization in anhydrous hydrogen fluoride with ammonium ions).
- Halogen Exchange Method
- Catalytic Halogenation
- Special Fluorinating Agent Method
Note: The diazotization fluorination method has been extensively studied.
Physicochemical Properties
| Property | Value |
|---|---|
| Appearance | Colorless transparent liquid |
| Melting Point | -56 °C |
| Boiling Point | 116 °C |
| Density | 1.0 g/cm³ |
| Flash Point | 23 °C (flammable) |
| Solubility | Insoluble in water; soluble in ethanol, ether, acetone, benzene, etc. |
Packaging & Storage
- Hazard Code: 32056 (flammable/explosive).
- Storage Conditions:
- Cool, ventilated warehouse (<30 °C).
- Away from fire/heat sources; fire/explosion-proof measures required.
- Packaging:
- Type: Plastic drums or plastic-lined metal drums.
- Capacity: 100 kg/drum or 200 kg/drum.
- Packing Class: II
- Symbol: 7
1. Basic Chemical Properties
| Property | Specification |
|---|---|
| Chemical Name | p-Fluorotoluene (4-Fluorotoluene) |
| Molecular Formula | C₇H₇F |
| Appearance | Clear colorless liquid |
| Melting Point | -56°C |
| Boiling Point | 115–117°C |
| Density (20°C) | 1.00–1.02 g/cm³ |
| Refractive Index | 1.470–1.473 |
| Solubility | Insoluble in water; miscible with organic solvents |
| Flash Point | 10–12°C (closed cup) |
2. Applications & Performance
| Application | Function | Key Benefit |
|---|---|---|
| Pharmaceuticals | Synthetic intermediate | Introduces fluorine into drug molecules |
| Agrochemicals | Building block for pesticides | Enhances bioactivity |
| Liquid Crystals | Fluorinated component | Improves thermal stability |
| Organic Synthesis | Arylating agent | Enables Friedel-Crafts reactions |
| Solvent | Specialty solvent | Low polarity, high volatility |
Key Features:
Electron-withdrawing fluorine activates benzene ring for electrophilic substitution
Stable under normal conditions (non-reactive with acids/bases)
Volatile organic compound (VOC) requiring controlled handling
3. Safety & Handling
| Parameter | Specification |
|---|---|
| Flammability | Highly flammable liquid (Class IB) |
| Skin Irritation | Mild irritant |
| Inhalation Risk | CNS depressant at high concentrations |
| Environmental Impact | Toxic to aquatic life |
| Storage Conditions | Cool, ventilated area (<25°C) |
| Shelf Life | Indefinite if properly stored |
| Regulatory Status | Listed in TSCA, REACH |
Summary
This monofluorinated aromatic compound serves as a versatile building block in pharmaceuticals and agrochemicals, leveraging its unique electronic properties for selective synthesis. Requires strict flammability controls during handling.
Disclaimer
The above content is for industry reference and exchange only. Accuracy/completeness is not guaranteed. Purchasers must comply with applicable laws and possess valid qualifications.
