Oxytocin CAS: 50-56-6
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
White crystalline powder, hygroscopic, soluble in water. Used as a contraceptive (uterotonic)
Appearance White or almost white powder
Dissolubility Very soluble in water. It dissolves in diluteSolutions of acetic acid and of ethanol (96%)
HPLC Retention time conforms to that of reference
Ph 3.0-6.0
Water (KF) ≤5.0%
Related substances(by HPLC) Individual ≤1.5%Together ≤5.0%
Amino acids Asp 0.90~1.10Glu 0.90~1.10Pro 0.90~1.10Gly 0.90~1.10Leu 0.90~1.10Ile 0.90~1.10Tyr 0.70~1.05Half-Cys 1.40~2.10
Acetic acid (by HPLC) 6%-10%
Bacterial endotoxin <300 IU/mg
Total bacterial count ≤100 CFU/g
Assay (by HPLC) 93.0%~102.0%
Activity Potency≥480 IU/mg
Conclusion It conforms to EP 8.0 and USP 37.
Storage Protection to light, at a temperature of 2 °C to 8 °C.
Package: 10G/bag; 1KG/bag .
Storage: Protection to light, at a temperature of 2 °C to 8 °C. Avoid to moisture.
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Property
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Details
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Chemical Name
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Oxytocin
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CAS Number
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50 – 56 – 6
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Molecular Formula
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\(C_{43}H_{66}N_{12}O_{12}S_{2}\)
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Molecular Weight
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1007.2
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Molecular Structure
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It is a peptide hormone composed of 9 amino acids. The structure contains a ring formed by a disulfide bond between two cysteine residues, which is crucial for its biological activity. The sequence of amino acids is Cys – Tyr – Ile – Gln – Asn – Cys – Pro – Leu – Gly – NH₂.
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Appearance
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Usually appears as a white to off – white crystalline powder.
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Solubility
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Soluble in water and acetic acid. This solubility allows it to be easily dissolved in body fluids for proper physiological functioning.
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Physiological Role
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In Childbirth: It plays a central role in the process of labor. Oxytocin stimulates uterine contractions, which helps in the expulsion of the fetus from the uterus. It also promotes the release of prostaglandins, further enhancing uterine contractions. Milk Ejection: In lactating women, oxytocin is responsible for the milk – ejection reflex. When a baby suckles, nerve signals trigger the release of oxytocin from the posterior pituitary gland, causing the myoepithelial cells around the mammary alveoli to contract and eject milk. Social and Emotional Function: Oxytocin is also involved in social bonding, trust, and pair – bonding. It has been associated with feelings of empathy, love, and attachment in both humans and animals.
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Medical Applications
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Induction of Labor: When necessary, synthetic oxytocin (pitocin) can be administered intravenously to induce labor in cases where the pregnancy has reached full – term or when there are medical indications for early delivery. Controlling Postpartum Hemorrhage: It is used to reduce bleeding after childbirth by promoting uterine contractions, which helps to compress the blood vessels in the uterus.
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Stability
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Oxytocin is relatively stable under appropriate storage conditions, typically refrigerated. However, exposure to heat, light, or extreme pH can degrade the hormone and reduce its activity.
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Safety Considerations
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When used appropriately in medical settings, oxytocin is generally safe. But excessive or improper use can lead to strong and uncoordinated uterine contractions, which may pose risks to both the mother and the fetus. In some cases, it can cause water intoxication if large amounts are administered without proper fluid balance management.
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