Active Pharmaceutical Ingredients

Molecular Formula： C22H25ClN2O9

Molecular Weight： 496.89

CAS No.: 2058-46-0

It is a broad-spectrum antibacterial agent. Many Rickettsia, mycoplasma, chlamydia, spirochetes, amoeba and some malaria parasites are also sensitive to this product. Enterococcus is resistant to it. Others such as actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter and Yersinia are sensitive to this product.

Description：It is yellow crystalline powder, odorless and bitter; It has hygroscopicity; In case of light, the color changes deeply, and it is easy to be damaged and invalid in alkali solution. Soluble in water, slightly soluble in ethanol, insoluble in chloroform or ether.

Application：The antibacterial spectrum and application are the same as tetracycline. This product is slightly more effective than tetracycline on intestinal infections, including amoebic dysentery.

Packing：25kg/drum or as customer’s requirements.

Storage：Store in airtight, tamper- proof container.

Oxytetracycline Hydrochloride: A Veterinary Antibiotic

Oxytetracycline Hydrochloride is an important antibiotic in veterinary medicine, widely used for treating various bacterial infections in animals.

1. General Characteristics

Aspect	Details
Classification	Tetracycline – class antibiotic
Source	Originally isolated from Streptomyces rimosus. Can also be produced semi – synthetically
Formulation	Available as powders, tablets, capsules, injectable solutions, and topical preparations. Feed premixes are common for livestock
Solubility	Soluble in water, which is beneficial for different routes of administration. For example, it can be added to drinking water for poultry and livestock or used for intravenous/intramuscular injections

2. Mechanism of Action

Action	Explanation
Inhibition of Protein Synthesis	Oxytetracycline Hydrochloride binds to the 30S ribosomal subunit of bacteria. This binding blocks the attachment of amino – acyl tRNA to the acceptor site on the ribosome – mRNA complex. As a result, the addition of new amino acids to the growing polypeptide chain is prevented, inhibiting bacterial protein synthesis
Selective Activity	It has a broad – spectrum antibacterial effect. It targets both Gram – positive and Gram – negative bacteria. Additionally, it is effective against certain mycoplasmas, rickettsiae, and chlamydiae. The unique structure of the ribosomes in these organisms allows for specific binding of oxytetracycline hydrochloride

3. Clinical Applications and Considerations

Category	Details
Applications	– Treating respiratory tract infections in cattle, swine, and poultry. In cattle, it can combat Pasteurella multocida and Mycoplasma bovis. In poultry, it is effective against Escherichia coli, Pasteurella multocida, and Mycoplasma gallisepticum. – Used to control skin and soft – tissue infections in animals, often caused by Staphylococcus spp. and Streptococcus spp. – Employed in aquaculture to treat bacterial diseases in fish, such as Aeromonas hydrophila infections
Considerations	– Overuse can lead to the development of antibiotic – resistant bacteria. Adhering to proper dosage and treatment duration as prescribed by veterinarians is crucial. – Can cause gastrointestinal upset in animals, including nausea, vomiting, and diarrhea. It may also disrupt the normal gut microbiota. – In young animals, it can cause discoloration of teeth and affect bone growth if used during tooth and bone development stages. – Caution is required when using it in combination with other drugs. For example, it may interact with calcium – containing compounds, reducing its absorption

Oxytetracycline Hydrochloride plays a vital role in maintaining the health and productivity of livestock, poultry, and in aquaculture through effective treatment of bacterial infections.

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