Active Pharmaceutical Ingredients

Molecular Formula： C22H24N2O9

Molecular Weight ： 460.434

CAS No.： 79-57-2

Oxytetracycline, a broad-spectrum antibiotic, can inhibit Gram-positive and negative bacteria, Eperythrozoon, chlamydia, mycoplasma, Rickettsia, spirochetes, actinomycetes, Vibrio and some protozoa (such as coccidia).

Description：It is yellow crystalline powder, odorless and bitter; It has hygroscopicity; In case of light, the color changes deeply, and it is easy to be damaged and invalid in alkali solution. Soluble in water, slightly soluble in ethanol, insoluble in chloroform or ether.

Application：It has strong antibacterial activity against Staphylococcus aureus, pneumococcus, Streptococcus pyogenes, Neisseria gonorrhoeae, meningococcus, Escherichia coli, aerogenes, Shigella, Yersinia chemicalbook, Listeria monocytogenes, etc; In addition, oxytetracycline also has strong effects on Rickettsia, mycoplasma, chlamydia and actinomycetes.

Packing：25kg/ bag or as customer’s requirements.

Storage：Preserve in well-closed container.

Minimum Order

One package

Oxytetracycline Base: A Veterinary Antibiotic

Oxytetracycline Base is an essential antibiotic in the veterinary field, utilized for combating a variety of bacterial infections in animals.

1. General Characteristics

Aspect	Details
Classification	Tetracycline – class antibiotic
Source	Derived from Streptomyces rimosus. It can also be obtained through semi – synthetic methods.
Formulation	Usually available as powders, which can be formulated into different dosage forms such as feed additives, oral suspensions, and sometimes in topical ointments for external use.
Solubility	Sparingly soluble in water. This property affects its administration routes, and special formulations or carriers may be needed to enhance its bioavailability in animals.

2. Mechanism of Action

Action	Explanation
Inhibition of Protein Synthesis	Oxytetracycline Base binds to the 30S ribosomal subunit of bacteria. This binding obstructs the attachment of amino – acyl tRNA to the acceptor site on the ribosome – mRNA complex. Consequently, the addition of new amino acids to the growing polypeptide chain is halted, effectively inhibiting bacterial protein synthesis.
Selective Activity	It exhibits a broad – spectrum antibacterial action. It targets both Gram – positive and Gram – negative bacteria. Additionally, it shows activity against certain mycoplasmas, rickettsiae, and chlamydiae. The distinct structure of the ribosomes in these organisms enables specific binding of oxytetracycline base, allowing it to exert its antibacterial effects.

3. Clinical Applications and Considerations

Category	Details
Applications	– Treating respiratory tract infections in cattle, swine, and poultry. In cattle, it can be used to combat infections caused by Pasteurella multocida and Mycoplasma bovis. In poultry, it is effective against Escherichia coli, Pasteurella multocida, and Mycoplasma gallisepticum. – Used to control skin and soft – tissue infections in animals, often caused by Staphylococcus spp. and Streptococcus spp. – Employed in aquaculture to treat bacterial diseases in fish, such as Aeromonas hydrophila infections.
Considerations	– Overuse can contribute to the development of antibiotic – resistant bacteria. It is crucial to adhere to proper dosage and treatment duration as prescribed by veterinarians. – May cause gastrointestinal disturbances in animals, including nausea, vomiting, and diarrhea. It can also disrupt the normal balance of gut microbiota. – In young animals, its use during tooth and bone development stages may lead to tooth discoloration and affect bone growth. – Caution is required when using it in combination with other drugs. For example, it may interact with calcium – containing compounds, reducing its absorption.

Oxytetracycline Base plays a significant role in maintaining the health and productivity of livestock, poultry, and in aquaculture by effectively treating bacterial infections.

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