Oxfendazole CAS NO.53716-50-0
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017083
CAS NO.53716-50-0
Purity 98%
MDL NumberMFCD00801063
EINEC Molecular Formula C15H13N3O3S
Molecular Weight 315.347
| Aspect | Details |
|---|---|
| Chemical Structure | – Molecular Formula: C₁₅H₁₃N₃O₃S<br>- Molecular Weight: 303.34 g/mol<br>- IUPAC Name: Methyl 5-(phenylsulfinyl)-2-benzimidazolecarbamate |
| Mechanism of Action | – Oxfendazole is a broad-spectrum benzimidazole anthelmintic that inhibits microtubule assembly by binding to tubulin. This disrupts the cytoskeleton, subcellular organelle migration, and cell division in parasites.<br>- It is more potent against helminth microtubule formation compared to mammalian tubulin, making it a selective antiparasitic agent. |
| Clinical Uses | – Used to treat parasitic infections, including trichuriasis (caused by Trichuris trichiura) and neurocysticercosis (caused by Taenia solium larval cysts).<br>- Demonstrated superior antiparasitic efficacy compared to albendazole in preclinical models. |
| Pharmacokinetics | – Absorption: Oxfendazole exhibits nonlinear pharmacokinetics, with dose-normalized exposure decreasing as the dose increases.<br>- Metabolism: Metabolized to oxfendazole sulfone and fenbendazole. The primary route of elimination is through biliary excretion.<br>- Half-Life: Longer than albendazole, with higher exposure in several animal species. |
| Physical Properties | – Solubility: Low solubility and high permeability (BCS Class II drug).<br>- Appearance: White to off-white solid. |
| Storage Conditions | Store in a cool, dry place, protected from moisture. |
| Research Applications | – Investigated for its potential as an improved anthelmintic agent for difficult-to-treat parasitic infections.<br>- Studied in various animal models to evaluate its efficacy and safety |
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