Orlistat
Pharmaceutical Materials 2025-03-02
CAS Number: 96829-58-2
Molecular Formula: C29H53NO5
Molecular Weight: 495.735 g/mol
Appearance: White crystalline powder
Usage: Used as an anti-obesity drug by inhibiting the absorption of dietary fat.
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| Category | Details |
|---|---|
| Chemical Name | Orlistat |
| Brand Names | Xenical, Alli (OTC in the US), and others |
| CAS Number | 96829-58-2 |
| Molecular Formula | C29H53NO5 |
| Molecular Weight | 495.73 g/mol |
| Chemical Class | Lipase inhibitor |
| Mechanism of Action | Inhibits the activity of gastrointestinal lipases, preventing the hydrolysis of triglycerides into fatty acids and monoglycerides, thereby reducing the absorption of dietary fat. |
| Indication | For the management of obesity, including weight loss and the maintenance of weight loss, in conjunction with a reduced-calorie diet. |
| Dosage | Typically 120 mg taken with each main meal or up to three times daily. Should not be taken if a meal is missed or does not contain fat. |
| Route of Administration | Oral |
| Contraindications | Pregnancy, breastfeeding, hypersensitivity to orlistat, chronic malabsorption syndrome, cholestasis, and concurrent use with certain medications (e.g., amiodarone). |
| Adverse Effects | Common: oily spotting, flatulence, fecal urgency, fatty/oily stool, increased defecation, fecal incontinence. Less common: respiratory infections, headaches, menstrual irregularities, anxiety, fatigue, urinary tract infections. Rare: allergic reactions, liver injury. |
| Special Precautions | Monitor for changes in vitamin status, especially fat-soluble vitamins (A, D, E, K). Consult a healthcare provider before use if taking other medications or have underlying medical conditions. |
| Regulatory Status | Approved for use as a prescription medication in many countries and as an OTC medication (Alli) in the US for weight management. |
