Obeticholic Acid CAS NO.:459789-99-2
Pharmaceutical Materials 2025-03-02
Catalog ID:89440
CAS NO.:459789-99-2
MDL Number:MFCD16621104
Molecular Weight:420.63
Obeticholic Acid, with the CAS NO. 459789-99-2, is a potent and selective agonist of the farnesoid X receptor (FXR). It is a derivative of chenodeoxycholic acid and has been developed as a therapeutic agent for the treatment of various liver diseases, including primary biliary cirrhosis and non-alcoholic fatty liver disease. By activating FXR, Obeticholic Acid indirectly inhibits the expression of cholesterol 7α-hydroxylase (CYP7A1), a key enzyme in bile acid synthesis, thereby reducing bile acid production. This compound exhibits promising pharmacological properties and has undergone extensive clinical trials, demonstrating its efficacy and safety in managing liver disorders.
| Property | Value |
|---|---|
| CAS NO. | 459789-99-2 |
| Molecular Formula | C26H44O4 |
| Molecular Weight | 420.63 g/mol |
| Density | 1.1±0.1 g/cm³ |
| Melting Point | N/A (not reported) |
| Boiling Point | 562.9±25.0°C at 760 mmHg |
| Flash Point | 308.3±19.7°C |
| Appearance | White to off-white powder |
| Solubility | Insoluble in water, soluble in DMSO and ethanol |
| Chemical Structure | Derivative of chenodeoxycholic acid |
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