Pharmaceutical Materials

Preparation method of o-fluorobenzoyl chloride, including the following steps: (1) the synthesis of o-fluorobenzotrichlorobian: o-fluorotoluene and triethanol are mixed, heated, adding azodiisobutyronitrile, and starting to pass chlorine, to obtain the intermediate o-fluorobenzotrichlorobian; (2) the synthesis of o-fluorobenzoyl chloride: the o-fluorobenzotrichlorobian obtained in step (1) is obtained in a stirring condition, elevating the temperature and maintaining a micro-negative pressure, and starting to slowly drop 0.5% zinc chloride Aqueous solution of 0.5% zinc chloride, 3 hours; if the o-fluorobenzoyl chloride is not completely transformed, then make up drops of aqueous zinc chloride until the o-fluorobenzoyl chloride is completely transformed, purified by means of decompression distillation, collected 100 ~ 105 ℃ fractions, to obtain the o-fluorobenzoyl chloride. The preparation method of o-fluorobenzoyl chloride has the advantages of fewer steps, higher yield and higher purity.,Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.

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