Nomilin
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80019072
CAS NO.1063-77-0
Purity 98%
MDL NumberMFCD00075979
Molecular Formula C28H34O9
Molecular Weight 514.56
Melting point: 278~279°C
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C28H34O9<br> Molecular weight: 514.56<br> CAS Number: 1063-77-0 |
| Physical Properties | White to off-white solid, soluble in DMSO (100 mg/mL) |
| Biological Activities | Anticancer: Exhibits antiproliferative activity against human breast cancer cells (MCF-7, MDA-MB-435) .<br> Neuroprotective: Mitigates cell death and reduces ROS production in SH-SY5Y cells under oxygen-glucose deprivation .<br> Anti-inflammatory and Antioxidant: Reduces inflammation and oxidative stress in various models .<br> Anti-obesity and Anti-hyperglycemic: Exhibits anti-obesity and anti-hyperglycemic effects .<br> Lifespan Extension: Extends lifespan in C. elegans and improves healthspan in doxorubicin-induced senescence mice . |
| Mechanism of Action | Anticancer: Inhibits cell proliferation through mechanisms involving Nrf2 signaling .<br> Neuroprotective: Acts via Nrf2-dependent pathways to protect against oxidative stress .<br> Lifespan Extension: Acts as a Pregnane X receptor (PXR) agonist, enhancing detoxification gene expression . |
| Applications | Research: Used in studies related to cancer, neuroprotection, inflammation, and lifespan extension .<br> Pharmaceutical: Potential therapeutic use for anticancer, anti-inflammatory, and anti-obesity treatments . |
| Storage Conditions | Store at 4°C, protect from light. In solvent: -80°C (6 months), -20°C (1 month) |
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