Agrochemicals

N,O-Dimethylhydroxylamine Hydrochloride (CAS No. 6638-79-5) 

1. Basic Information

• Chemical Name: N,O-Dimethylhydroxylamine hydrochloride
• Synonyms:
  • Weinreb amine hydrochloride
  • N-Methyl-O-methylhydroxylamine hydrochloride
• CAS Number: 6638-79-5
• Molecular Formula: C₂H₈ClNO
• Molecular Weight: 97.54 g/mol
• Appearance: White to off-white crystalline powder
• Odor: Odorless or faint amine-like odor

2. Physical and Chemical Properties

• Melting Point: 108-112°C (226-234°F) (dec.)
• Solubility:
  • Water: Highly soluble
  • Organic solvents: Soluble in methanol, ethanol; slightly soluble in acetone
• pH (1% solution): ~3-5 (acidic)
• Hygroscopicity: Absorbs moisture from air

3. Chemical Structure

   CH₃
    |
CH₃-N-OH · HCl
    |
    O

4. Hazards (GHS Classification)

• Acute Toxicity: Harmful if swallowed (H302)
• Skin Irritation: Causes skin irritation (H315)
• Eye Irritation: Causes serious eye irritation (H319)
• Respiratory Irritation: May cause respiratory irritation (H335)
• NFPA Rating: Health 2, Flammability 1, Reactivity 0

5. Storage and Handling

• Storage:
  • Keep container tightly closed in a cool, dry place (<25°C)
  • Store under inert gas (N₂/Ar) for long-term preservation
• Handling:
  • Use nitrile gloves and safety goggles
  • Handle in a well-ventilated area or fume hood

6. Applications

• Organic Synthesis:
  • Key reagent in Weinreb ketone synthesis
  • Amide formation from esters
• Pharmaceutical Intermediates: Production of APIs

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