N,O-Bis(trimethylsilyl)acetamide
Pharmaceutical Materials 2025-03-02
CAS Number: 10416-59-8
Molecular Formula: C8H21NOSi2
Molecular Weight: 203.43 g/mol
Appearance: Colorless to light yellow liquid
Melting Point: 24 °C
Boiling Point: 71-73 °C (35 mmHg)
Density: 0.832 g/mL at 20 °C
Usage: Important pharmaceutical intermediate.
| Property | Details |
|---|---|
| Chemical Name | N,O-Bis(trimethylsilyl)acetamide |
| Synonyms | BSA; Bis(trimethylsilyl)acetamide; N,O-Bis(trimethylsilyl)ethanimidate |
| CAS Number | 10416-59-8 |
| EINECS Number | 233-892-7 |
| Molecular Formula | C₈H₂₁NOSi₂ |
| Molecular Weight | 203.43 g/mol |
| Physical State | Colorless to pale yellow liquid |
| Melting Point | 24 °C |
| Boiling Point | 162.08 °C (760 mmHg) |
| Density | 0.831 g/cm³ (20 °C) |
| Solubility | Soluble in organic solvents; hydrolyzes in water |
| Applications | – Pharmaceuticals: Key intermediate in the synthesis of cephalosporin antibiotics. – Silylating Agent: Protects amino acids, carboxylic acids, and alcohols during organic reactions. – Chromatography: Used for modifying stationary phases and polar groups in analytical chemistry. |
| Health & Safety | – Toxicity: Flammable, corrosive, and toxic; causes severe eye and skin irritation. – Handling: Store under inert gas at 0-6 °C to prevent degradation. – Emergency Response: In case of exposure, flush with water and seek medical attention immediately. |
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