N,N-Dimethylformamide dimethyl acetal CAS No.4637-24-5
Pharmaceutical Materials 2025-03-21
CAS No.4637-24-5
| Category | Details |
|---|---|
| Chemical Name | N,N-Dimethylformamide dimethyl acetal |
| CAS Number | 4637-24-5 |
| Other Names | DMF-DMA; 1.1-Dimethoxytrimethylamine; N,N-Dimethylformamide dimethyl ether, etc. |
| Molecular Formula | C5H13NO2 |
| Molecular Weight | 119.16 g/mol |
| Appearance | Colorless to white liquid |
| Melting Point | -85°C |
| Boiling Point | 102-103°C (720 mmHg) |
| Density | 0.897 g/mL at 25°C |
| Refractive Index | 1.396 (lit.) |
| Flash Point | 45°F (-7.22°C) |
| Solubility | Miscible with most organic solvents |
| Uses | Important intermediate in the synthesis of heterocyclic compounds; serves as a methylating agent and esterification dehydration agent; widely used in pharmaceutical synthesis, particularly in the synthesis of drugs like oxafloxacin, milrinone, and allopurinol. |
| Synthesis Method | Typically synthesized by reacting N,N-dimethylformamide with dimethyl sulfate to form an imine complex, which is then reacted with solid sodium methoxide dispersed in an organic solvent such as isoparaffins, solvent oil, or white oil. |
| Safety Information | May cause irritation to skin and eyes; handle in a well-ventilated area; avoid contact with ignition sources; store below +30°C; in case of contact, rinse with plenty of water and seek medical attention if necessary. |
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