Nitroxoline

Pharmaceutical Materials 2025-03-02

CAS Number: 4008-48-4

Molecular Formula: C9H6N2O3

Molecular Weight: 190.15 g/mol

Appearance: White to pale yellow crystals

Melting Point: Not available (varies with purity)

Solubility: Insoluble in water and low-polarity ethers, soluble in DMSO

Usage: Used as an antiseptic, disinfectant, insecticide, and in the synthesis of anti-infective drugs.

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Attribute Details
Name Nitroxoline
Synonyms 8-Hydroxy-5-nitroquinoline, 5-Nitro-8-quinolinol, 5-nitroquinolin-8-ol
CAS Number 4008-48-4
Molecular Formula C9H6N2O3
Molecular Weight 190.16 g/mol
Chemical Structure A quinoline derivative with a nitro group at position 5 and a hydroxy group at position 8
Appearance White to brown solid powder (may also be described as yellow crystalline solid)
Physical Properties
  • Soluble in DMSO, but insoluble in water and low-polarity ether solvents
  • Good chemical stability
Chemical Properties
  • Antibacterial agent with specific physiological activity and good coordination ability
  • Can chelate with metal ions such as zinc
  • Has a fluorescent property
Medical Uses
  • Used as an orally active antibiofilm agent
  • Reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms
  • Can be used for urinary tract infections and cancer research
  • Potential as an antifungal and antiparasitic agent
Synthesis Methods Synthesized by directed nitrosation of 8-hydroxyquinoline with nitrous acid, followed by oxidation with dilute nitric acid
Safety Information
  • Handle with appropriate personal protective equipment
  • Follow relevant safety guidelines and regulations
  • Store in a cool, dry place away from heat and sources of ignition