Nimesulide CAS NO.51803-78-2
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017220
CAS NO.51803-78-2
Purity 98%
MDL NumberMFCD00079470
Molecular FormulaC13H12N2O5S
Molecular Weight 308.3098
Melting point: 143~144.5°C
| Aspect | Details |
|---|---|
| Chemical Properties | – Molecular Formula: C13H12N2O5S<br>- Molecular Weight: 324.31 g/mol<br>- CAS Number: 51803-78-2<br>- Appearance: Yellow needle-like crystals |
| Mechanism of Action | Nimesulide is a selective COX-2 inhibitor that reduces inflammation and pain by blocking the production of prostaglandins. It also has antipyretic effects. |
| Indications | – Treatment of acute pain.<br>- Symptomatic treatment of osteoarthritis.<br>- Primary dysmenorrhea in adolescents and adults above 12 years old. |
| Dosage Forms | – Oral capsules (100 mg)<br>- Oral granules for suspension (100 mg)<br>- Suppositories (200 mg)<br>- Topical gels and sprays |
| Administration | – Acute Pain: 100 mg twice daily for no more than 15 days.<br>- Osteoarthritis: 100 mg twice daily.<br>- Dysmenorrhea: 100 mg twice daily. |
| Adverse Effects | – Common: Headache, dizziness, somnolence, gastrointestinal upset, nausea, abdominal discomfort, diarrhea.<br>- Serious: Acute liver injury, hepatotoxicity, acute liver failure. |
| Contraindications | – History of severe liver disease.<br>- Long-term use is not recommended due to hepatotoxicity. |
| Special Considerations | – Monitor liver function regularly.<br>- Not approved for use in the US due to safety concerns.<br>- Withdrawn from the market in many countries. |
| Storage Conditions | Store in a cool, dry place, protected from light and moisture |
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