NH2-PEG2-CH2COOH CAS NO.:134978-97-5
Pharmaceutical Materials 2025-03-02
Catalog ID:10803
CAS NO.:134978-97-5
Purity:≥95%
Molecular Weight:163.2
Appearance: Colorless to light yellow liquid
NH2-PEG2-CH2COOH, with its CAS number 134978-97-5, is a versatile PEG derivative that combines an amino group with a carboxylic acid functionality, linked through a PEG chain. This compound is widely used in biochemical and pharmaceutical applications due to its excellent water solubility, biocompatibility, and reactivity. The amino group allows for easy functionalization, while the carboxylic acid group can form stable amide bonds with other molecules. NH2-PEG2-CH2COOH is particularly useful as a linker in PROTAC (proteolysis-targeting chimera) synthesis, enabling the selective degradation of target proteins.
| Property | Details |
|---|---|
| CAS Number | 134978-97-5 |
| Chemical Name | NH2-PEG2-CH2COOH |
| Molecular Formula | C6H13NO4 |
| Molecular Weight | 163.17 g/mol |
| Appearance | White to off-white powder or crystals |
| Melting Point | 124.0 to 128.0°C |
| Boiling Point | 323.8±22.0°C at 760 mmHg |
| Density | 1.177 g/cm³ |
| Solubility | Soluble in DMSO, methanol, water, etc. |
| Storage Condition | Keep in dark place, store in freezer under -20°C |
| Uses | PROTAC linker, biochemical modifier, pharmaceutical intermediate |
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