Nepafenac
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
English Synonyms 2-Amino-3-benzoylbenzeneacetamide
Catalog ID95460
CAS NO.78281-72-8
Purity 98%
MDL NumberMFCD08067732
EINEC Molecular Formula C15H14N2O2
Molecular Weight 254.284
| Category | Content |
|---|---|
| Generic Name | Nepafenac |
| Chemical Formula | C15H14N2O2 |
| CAS Number | 78281-72-8 |
| Mechanism of Action | Nepafenac is a prodrug that is rapidly converted to its active metabolite, amfenac, in ocular tissues. Amfenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing the synthesis of prostaglandins and thereby decreasing inflammation and pain. |
| Indications | – Used to treat ocular pain and inflammation associated with cataract surgery.<br>- May also be used for other ophthalmic conditions as determined by a healthcare provider. |
| Dosage Forms | 0.1% ophthalmic suspension (eye drops) |
| Administration | – Administered topically to the eye.<br>- Shake well before use.<br>- If using multiple eye medications, administer at least 5 minutes apart. |
| Pharmacokinetics | – Rapidly crosses the cornea, achieving higher intraocular concentrations compared to conventional NSAIDs.<br>- Metabolized to amfenac primarily in the iris, ciliary body, retina, and choroid. |
| Side Effects | – Common: Secondary cataract, decreased visual acuity, foreign body sensation, increased intraocular pressure, sticky feeling in the eye.<br>- Serious: Allergic reactions (e.g., swelling, difficulty breathing), delayed healing, corneal complications. |
| Precautions | – Not recommended for patients allergic to NSAIDs or any components of the product.<br>- Avoid contamination of the eye drop container to prevent infections.<br>- Do not wear contact lenses during treatment.<br>- Monitor for delayed healing, especially when used with corticosteroids. |
| Storage | Store at temperatures between 36°F to 77°F (2°C to 25°C) |
| Developer | Alcon Laboratories (originally AH Robins) |
| Brand Name | Nevanac |
| Approval Date | FDA approval on August 19, 2005. |
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