Pharmaceutical Materials

Usage： Neomycin sulfate, is used as broad-spectrum antibiotic, has a good function of prevention and cure of illeness (dysentery, diarrhea, maldevelopment) dysenterywhich caused by Escherichia coli, salmonella, staphylococcus aureus, Corynebacterium diphtheriae.

Packaging and Shipping： 25KG/drum or according to clients’ requirements.

Storage： in a dry and ventilated warehouse; keep away from sunshine and moisture.

 

Name	Neomycin Sulphate
Synonyms	neomix mycigient neobiotic neofracin newfrancef neo-mantlecreme Nystatin sulfate neomycinesulfate Neomycin Sulfate Neomycin Sulphate mycifradin sulfate FRADIOMYCIN SULFATE NEOMYCIN SULPHATE pure (2S,3S,4S,5S,6S)-5-amino-2-(aminomethyl)-6-[(1S,2S,3S,4R,6R)-4,6-diamino-2-[(2R,3S,4R,5S)-4-[(2S,3S,4S,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol,sulfuric acid
CAS	1405-10-3
EINECS	215-773-1
InChI	InChI=1/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6-,7+,8-,9+,10+,11+,12+,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23-;/m1./s1
InChIKey	OIXVKQDWLFHVGR-VTSVPHRWSA-N

Molecular Formula	C23H48N6O17S
Molar Mass	712.72
Melting Point	>187°C (dec.)
Boling Point	1046.1°C at 760 mmHg
Specific Rotation(α)	D20 +54° (c = 2 in H2O)
Flash Point	56℃
Water Solubility	Soluble in water
Solubility	H2O: 50mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.
Vapor Presure	0mmHg at 25°C
Appearance	White to light yellow powder
Color	white to slightly yellow
Merck	14,6454
PH	5.0-7.5 (50g/l, H2O, 20℃)
Storage Condition	2-8°C
Stability	Stable. Incompatible with strong oxidizing agents.
Sensitive	Sensitive to light and humidity
Refractive Index	56 ° (C=10, H2O)
MDL	MFCD00077833
Use	For broad-spectrum antibiotics, Staphylococcus aureus, diphtheria and Bacillus anthracis good
In vitro study	The Neomycin interacts preferentially with the ribozyme-substrate complex, and this interaction leads to a reduction in the rate of cleavage, by stabilizing the ground state of the complex and destabilizing the transition state of the cleavage step. Neomycin causes a conformational change in the structure of the transactivation Region (TAR), which can be detected by circular dichroism spectroscopy. Neomycin acts as a non-competitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (Koff) for the dissociation of RNA and peptides. Neomycin is the most potent of the aminoglycosides (groove binders) used to stabilize the triple helix of DNA. Neomycin stabilizes TAT, as well as the mixed-base DNA triple helix, better than the known DNA minor groove binders (which normally disrupt the triple helix) and polyamines. Neomycin stabilizes the TAT triple helix better, but can also stabilize the CGC() triple helix. Neomycin concentration-and voltage-dependent induction of partial inhibition of channels in the cytosolic and luminal surfaces. Neomycin has a greater affinity for the lumen than for the cytoplasm: the dissociation constants at zero voltage (Kb(0)) are 210.2 nM and 589.7 nM, respectively. Neomycin also showed voltage-dependent remission of inhibition at potentials greater than 60 mV.

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