Active Pharmaceutical Ingredients

Catalog ID80017804

CAS NO.357-08-4

Purity 98%

MDL NumberMFCD00069322

EINEC206-611-0

Molecular FormulaC19H22ClNO4

Molecular Weight363.8353

Melting point: 130~135°C

Aspect	Details
Mechanism of Action	Naloxone hydrochloride is an opioid antagonist that competitively binds to µ, κ, and σ opioid receptors in the central nervous system (CNS), with the highest affinity for the µ receptor. It rapidly reverses the effects of opioids, including respiratory depression and sedation, by displacing opioids from their receptors.
Storage Conditions	– Injection Vials and Ampuls: Store at 20–25°C (68–77°F); protect from light.<br>- Prefilled Syringes (e.g., Zimhi): Store at 20–25°C (68–77°F); excursions permitted to 15–30°C (59–86°F). Do not refrigerate.<br>- Nasal Sprays (e.g., Narcan, Kloxxado): Store at 15–20°C (59–68°F); excursions permitted to temperatures up to 40°C (104°F). Do not freeze.
Special Considerations	– Titration: Administer slowly to achieve the desired effect. Complete reversal of high opioid doses can result in total reversal of analgesia and other adverse effects, including hypertension and agitation.<br>- Cardiovascular Risks: Use with caution in patients with preexisting cardiovascular disease. Naloxone can cause hypotension, hypertension, ventricular tachycardia/fibrillation, and pulmonary edema.<br>- Opioid Withdrawal: May precipitate severe opioid withdrawal symptoms, especially in patients physically dependent on opioids. Symptoms include nausea, vomiting, sweating, tremor, tachycardia, hypertension, and seizures.<br>- Recurrent Depression: Monitor patients closely for recurrent respiratory and CNS depression, as the duration of action of most opioids may exceed that of naloxone.<br>- Accidental Needlestick: Caution with prefilled syringes to avoid accidental needlestick injuries.<br>- Pregnancy and Lactation: Use only when clearly needed in pregnant women, as naloxone crosses the placenta and may cause fetal distress. Caution is also advised in nursing mothers.

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