N-(Trimethylsilyl)imidazole
Pharmaceutical Materials 2025-03-02
CAS Number: 18156-74-6
Molecular Formula: C6H12N2Si
Molecular Weight: 140.26 g/mol
Appearance: Clear colorless to yellow liquid
Melting Point: -42°C
Boiling Point: 93-94°C (13 mmHg)
Usage: Used as an antibiotic intermediate and a strong silylating agent.
| Property/Characteristic | Details |
|---|---|
| Chemical Name | N-(Trimethylsilyl)imidazole |
| CAS Number | 1815-17-4 |
| Synonyms | 1-Trimethylsilylimidazole, TMSI, Trimethylsilylimidazole |
| Molecular Formula | C6H12N2Si |
| Molecular Weight | 144.26 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 168-170°C (760 mmHg) |
| Density | 0.89 g/mL at 25°C |
| Flash Point | 55°C |
| Refractive Index | 1.466-1.468 at 20°C |
| Solubility | Soluble in organic solvents such as toluene, ether, and tetrahydrofuran |
| Stability | Stable under normal conditions; reacts with water to form imidazole and trimethylsilanol |
| Hazard Information | Flammable; irritating to eyes, skin, and respiratory system; may cause severe burns; keep away from sources of ignition and incompatible materials |
| Primary Uses | Used as a silylating agent in organic synthesis, particularly for the protection of hydroxyl and amino groups; also used as a catalyst in condensation reactions and for the preparation of silicon-containing polymers |
| Handling Precautions | Wear appropriate personal protective equipment; handle in a well-ventilated area; avoid contact with skin, eyes, and clothing; store in a cool, dry place away from incompatible materials and sources of ignition |
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