Pharmaceutical Materials

Product Name

N-Methyldiethanolamine

N-Multiple Names

Methyldiethanolamine;

2.2-(Methylimino)Diethanol;

2.2-Methyliminodiethanol;

N-Methylediethanolamine;

N-Methyl Diethanolamine;

Methyl Diethanlamine;

2-Hydroxy-N-(2-Hydroxyethyl)-N-Methylethanaminium; MDEA; N,N-Bis(2-Hydroxyethyl)Methylamine

CAS No. 105-59-9

EC No. 203-312-7

MF No. C5H13NO2

MW No. 119.16372

Mainly used as emulsifier and acid gas absorbent, acid base control agent, polyurethane foam catalyst.

It is also used as an intermediate in antitumor drugs such as nitrogen mustard hydrochloride.

Advantage of N-Methyldiethanolamine CAS No. 105-59-9 Basic

Good intermediate

Wildly usage application

Good catalyst

Names and Identifiers

Name	N-Methyldiethanolamine
Synonyms	MDEA Methyl Diethanlamine METHYL DIETHANOLAMINE N-METHYLDIETHANOLAMINE N-Methyldiethanolamine N-Methyl Diethanolamine N-Methylediethanolamine 2,2-Methyliminodiethanol 2,2-(Methylimino)Diethanol N-METHYL-2,2′-IMINODIETHANOL BIS(2-HYDROXYETHYL)METHYLAMINE N-METHYL-2,2-IMINOBIS(ETHANOL) N,N-BIS(2-HYDROXYETHYL)METHYLAMINE N-METHYL-N-(2-HYDROXYETHYL)-2-AMINOETHANOL 2-hydroxy-N-(2-hydroxyethyl)-N-methylethanaminium
CAS	105-59-9
EINECS	203-312-7
InChI	InChI=1/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3/p+1
InChIKey	CRVGTESFCCXCTH-UHFFFAOYSA-N

105-59-9 – Physico-chemical Properties

Molecular Formula	C5H13NO2
Molar Mass	119.16
Density	1.038g/mLat 25°C(lit.)
Melting Point	-21 °C
Boling Point	246-248°C(lit.)
Flash Point	260°F
Water Solubility	MISCIBLE
Vapor Presure	0.01 mm Hg ( 20 °C)
Vapor Density	4 (vs air)
Appearance	Liquid
Color	Clear colorless to light yellow
Odor	Ammonical
BRN	1734441
pKa	14.41±0.10(Predicted)
PH	11.5 (100g/l, H2O, 20℃)
Storage Condition	Store below +30°C.
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Explosive Limit	0.9-8.4%(V)
Refractive Index	n20/D 1.469(lit.)
Physical and Chemical Properties	colorless or yellowish viscous liquid boiling point 246~248 ℃ flash point 260 ℃ freezing point -21 ℃ latent heat of vaporization 519.16KJ/Kg boiling point 247 ℃ water-soluble, soluble in water and alcohol, slightly soluble in ether
Use	It is a new solvent with excellent performance for selective desulfurization and decarburization. It has the advantages of high selectivity, less solvent consumption, remarkable energy saving effect, and not easy to degrade. Widely used in oil gas and gas desulfurization purification emulsifier and acid gas absorbent, acid-base control agent, polyurethane foam catalyst. The carbon dioxide in synthetic ammonia can be removed with the participation of an activator, so that it has been gradually promoted in the absorption of carbon dioxide in flue gas in recent years. In addition, MDEA can also be used as pesticides, emulsifiers, semi-finished products of fabric additives, intermediates of antineoplastic drug hydrochloric acid nitrogen mustard, catalyst of carbamate coatings, it is also a drying accelerator for paint.

105-59-9 – Risk and Safety

Hazard Symbols	Xi – Irritant
Risk Codes	36 – Irritating to the eyes
Safety Description	24 – Avoid contact with skin.
UN IDs	2735
WGK Germany	1
RTECS	KL7525000
TSCA	Yes
HS Code	2922 17 00
Hazard Class	8
Packing Group	II
Toxicity	LD50 orally in Rabbit: 4680 mg/kg

Reference Information

pH range of acid-base indicator discoloration	11.5 at 100g/l at 20°C
LogP	-1.16 at 23℃
purpose	mainly used as emulsifier and acid gas absorbent, acid-base control agent, polyurethane foam catalyst. It is also used as an intermediate of the antitumor drug nitrogen hydrochloride and the like.
production method	1. From the reaction of formaldehyde and diethanolamine. Formic acid was added to the reaction pot and heated to boiling, and a mixed solution of formaldehyde and diethanolamine was added dropwise under stirring for about 1H. The temperature was maintained at 90-98 ° C., and reflux was continued for 4 hours. Then, distillation under reduced pressure was carried out to collect a fraction at 120-130 ° C. (0.53kPa) to obtain N-methyldiethanolamine in a yield of 85%. Derived from the reaction of methylamine with ethylene oxide. The temperature was kept below 30 ° C., and the addition reaction was carried out by introducing ethylene oxide gas into 20% methylamine solution until the relative density of the reaction solution reached 1.025. Stirring for 15min, the relative density is unchanged for the end point. Methylamine was recovered to 103 ° C. Under normal pressure, and after water was evaporated under reduced pressure, a 119-170 ° C. (4.67kPa) fraction was collected. It is the finished product. The yield was 72%. Raw material consumption quota: Ethylene oxide 950kg/t, methylamine (40%)870kg/t. In addition, N-methyl diethanolamine can be obtained by catalytic hydrogenation of formaldehyde and cyanoethanol.
spontaneous combustion temperature	770 ° F.

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