N-(Hydroxymethyl)phthalimide
Pharmaceutical Materials 2025-03-02
CAS Number: 118-29-6
Molecular Formula: C9H7NO3
Molecular Weight: 177.16 g/mol
Appearance: White powder or crystalline solid
Usage: It is used as an intermediate in chemical synthesis, particularly in the pharmaceutical industry for the synthesis of drugs.
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| Category | Details |
|---|---|
| Chemical Name | N-(Hydroxymethyl)phthalimide |
| Synonyms | N-Hydroxymethyl phthalimide, NHMP, N-(Hydroxymethyl)phthalimide, N-(Hydroxymethyl)phthalimide, N-Hydroxymethylisoindoline-1.3-dione |
| CAS Number | 118-29-6 |
| Molecular Formula | C9H7NO3 |
| Molecular Weight | 177.16 g/mol |
| Appearance | White or pale yellow crystalline solid/powder |
| Density | 1.5 ± 0.1 g/cm³ |
| Melting Point | 142-149°C (literature values may vary) |
| Boiling Point | 332.0 ± 25.0°C at 760 mmHg |
| Flash Point | 154.6 ± 23.2°C |
| Solubility | Difficult to dissolve in common organic solvents |
| Synthesis Methods | – Reaction between phthalimide and formaldehyde – Reaction between phthalic acid and formaldehyde under acidic conditions followed by dehydration – Reaction between phthalimide and methanol or other hydroxyl-containing compounds in the presence of a catalyst |
| Applications | – Intermediate in the synthesis of pesticides, dyes, pigments, and pharmaceuticals – Used as a thickening agent and adhesive in certain resins and polymers – Intermediate in the synthesis of antimicrobial and anticancer drugs – Photosensitizer in photopolymerization reactions |
| Safety | Handle with caution; avoid skin contact and inhalation. Store in a cool, dry place, away from heat, moisture, and oxidizing agents. |
| Storage Conditions | Store in a tightly sealed container, in a cool, dry place, away from sources of ignition and incompatible materials. |
