Other Chemicals

N-(2-Hydroxyethyl)piperazine – Names and Identifiers

Name	N-(2-Hydroxyethyl)piperazine
Synonyms	NSC 38969 NSC 26884 NSC 60706 1-Piperazineethanol N-(2-Hydroxyethyl)pi Piperazineethanol, 1- Hydroxyethyl piperazine 2-piperazin-1-ylethanol 2-(1-Piperazino)ethanol 1-piperazin-1-ylethanol 1-(2-Hydroxyethyl)piperazine N-(2-Hydroxyethyl)piperazine N-(2-Hydroxyethyl) piperazine 1-(2-hydroxyethyl)piperazinediium (2E)-3-(naphthalen-2-yl)prop-2-enoic acid 2-(Piperazin-1-yl)ethan-1-ol, 1-Hydroxy-2-(piperazin-1-yl)ethane 1-(2-Hydroxyethyl)piperazine,2-Piperazinoethanol, Piperazine-1-ethanol
CAS	103-76-4
EINECS	203-142-3
InChI	InChI=1/C6H14N2O/c1-6(9)8-4-2-7-3-5-8/h6-7,9H,2-5H2,1H3

N-(2-Hydroxyethyl)piperazine – Physico-chemical Properties

Molecular Formula	C6H14N2O
Molar Mass	130.19
Density	1.061g/mLat 25°C(lit.)
Melting Point	-38.5 °C
Boling Point	246°C(lit.)
Flash Point	>230°F
Water Solubility	MISCIBLE
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	0.007 hPa (20 °C)
Appearance	Transparent, bright yellow liquid
Specific Gravity	1.060
Color	Clear colorless to pale yellow
BRN	104361
pKa	14.96±0.10(Predicted)
PH	12.3 (100g/l, H2O, 20℃)
Storage Condition	Store below +30°C.
Explosive Limit	1.4-8.9%(V)
Refractive Index	n20/D 1.506(lit.)
MDL	MFCD00005970
Physical and Chemical Properties	The boiling point of 246 deg C, the relative density of 1.061, refractive index of 1.5065.
Use	It is an important intermediate for the production of triethylenediamine, surfactants, pharmaceuticals and pesticides, and can be used to synthesize fluphenazine, a psychiatric drug, etc.

N-(2-Hydroxyethyl)piperazine – Risk and Safety

Hazard Symbols	Xi – Irritant
Risk Codes	R36/37/38 – Irritating to eyes, respiratory system and skin. R41 – Risk of serious damage to eyes R38 – Irritating to the skin
Safety Description	S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 – S37/39 – Wear suitable gloves and eye/face protection
WGK Germany	1
RTECS	TL6825000
TSCA	Yes
HS Code	29335995
Hazard Note	Irritant
Toxicity	LD50 orally in Rabbit: 4000 mg/kg LD50 dermal Rabbit > 5000 mg/kg

N-(2-Hydroxyethyl)piperazine – Reference Information

LogP	-1.47 at 25℃
NIST chemical information	Information provided by: webbook.nist.gov (external link)
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
use	is an important intermediate in the production of triethylenediamine, surfactant, medicine and pesticide. it can be used in the synthesis of psychotic fluphenazine, etc. it is used in organic synthesis and is an important intermediate in the production of triethylenediamine, surfactant, medicine and pesticide. It can also be used to synthesize psychotic fluphenazine, etc.
Production method	It is obtained by the reaction of piperazine hexahydrate and ethylene oxide. Dissolve piperazine hexahydrate in water, stir and cool to 15-20°C, and pass in ethylene oxide. After the passage is completed, the reaction is stirred at 30-35 ℃ for 2 hours, and the 90% of the original water added amount is steamed by heating. Cold to below 15 ℃, filter. The filtrate was distilled under reduced pressure, and the fraction at 145-155 ℃(5.33kPa) was collected to obtain N-(2-hydroxyethyl) piperazine.
spontaneous combustion temperature	280°C

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