N-(2-Hydroxyethyl)piperazine CAS 103-76-4
N-(2-Hydroxyethyl)piperazine – Names and Identifiers
Name
N-(2-Hydroxyethyl)piperazine
Synonyms
NSC 38969NSC 26884NSC 607061-PiperazineethanolN-(2-Hydroxyethyl)piPiperazineethanol, 1-Hyd...
Category：Other Chemicals
Introduction
N-(2-Hydroxyethyl)piperazine – Names and Identifiers
| Name | N-(2-Hydroxyethyl)piperazine |
| Synonyms | NSC 38969 NSC 26884 NSC 60706 1-Piperazineethanol N-(2-Hydroxyethyl)pi Piperazineethanol, 1- Hydroxyethyl piperazine 2-piperazin-1-ylethanol 2-(1-Piperazino)ethanol 1-piperazin-1-ylethanol 1-(2-Hydroxyethyl)piperazine N-(2-Hydroxyethyl)piperazine N-(2-Hydroxyethyl) piperazine 1-(2-hydroxyethyl)piperazinediium (2E)-3-(naphthalen-2-yl)prop-2-enoic acid 2-(Piperazin-1-yl)ethan-1-ol, 1-Hydroxy-2-(piperazin-1-yl)ethane 1-(2-Hydroxyethyl)piperazine,2-Piperazinoethanol, Piperazine-1-ethanol |
| CAS | 103-76-4 |
| EINECS | 203-142-3 |
| InChI | InChI=1/C6H14N2O/c1-6(9)8-4-2-7-3-5-8/h6-7,9H,2-5H2,1H3 |
N-(2-Hydroxyethyl)piperazine – Physico-chemical Properties
| Molecular Formula | C6H14N2O |
| Molar Mass | 130.19 |
| Density | 1.061g/mLat 25°C(lit.) |
| Melting Point | -38.5 °C |
| Boling Point | 246°C(lit.) |
| Flash Point | >230°F |
| Water Solubility | MISCIBLE |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.007 hPa (20 °C) |
| Appearance | Transparent, bright yellow liquid |
| Specific Gravity | 1.060 |
| Color | Clear colorless to pale yellow |
| BRN | 104361 |
| pKa | 14.96±0.10(Predicted) |
| PH | 12.3 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Explosive Limit | 1.4-8.9%(V) |
| Refractive Index | n20/D 1.506(lit.) |
| MDL | MFCD00005970 |
| Physical and Chemical Properties | The boiling point of 246 deg C, the relative density of 1.061, refractive index of 1.5065. |
| Use | It is an important intermediate for the production of triethylenediamine, surfactants, pharmaceuticals and pesticides, and can be used to synthesize fluphenazine, a psychiatric drug, etc. |
N-(2-Hydroxyethyl)piperazine – Risk and Safety
| Hazard Symbols | Xi – Irritant |
| Risk Codes | R36/37/38 – Irritating to eyes, respiratory system and skin. R41 – Risk of serious damage to eyes R38 – Irritating to the skin |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 – S37/39 – Wear suitable gloves and eye/face protection |
| WGK Germany | 1 |
| RTECS | TL6825000 |
| TSCA | Yes |
| HS Code | 29335995 |
| Hazard Note | Irritant |
| Toxicity | LD50 orally in Rabbit: 4000 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
N-(2-Hydroxyethyl)piperazine – Reference Information
| LogP | -1.47 at 25℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | is an important intermediate in the production of triethylenediamine, surfactant, medicine and pesticide. it can be used in the synthesis of psychotic fluphenazine, etc. it is used in organic synthesis and is an important intermediate in the production of triethylenediamine, surfactant, medicine and pesticide. It can also be used to synthesize psychotic fluphenazine, etc. |
| Production method | It is obtained by the reaction of piperazine hexahydrate and ethylene oxide. Dissolve piperazine hexahydrate in water, stir and cool to 15-20°C, and pass in ethylene oxide. After the passage is completed, the reaction is stirred at 30-35 ℃ for 2 hours, and the 90% of the original water added amount is steamed by heating. Cold to below 15 ℃, filter. The filtrate was distilled under reduced pressure, and the fraction at 145-155 ℃(5.33kPa) was collected to obtain N-(2-hydroxyethyl) piperazine. |
| spontaneous combustion temperature | 280°C |
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