mPEG-DSPE CAS NO.: 147867-65-0
Biomedicine 2025-03-04
CAS NO.: 147867-65-0
Product purity: ≥95%
Product Usage: Used in medical research, drug release, nanotechnology and new material research, cell culture. As well as ligand research, peptide synthesis support, grafted polymer compounds, new materials and polyethylene glycol modified functional coatings and other active compounds.
mPEG-DSPE: Basic Information
| Aspect | Details |
|---|---|
| Chemical Name | mPEG-DSPE (Methoxy Polyethylene Glycol-Distearoyl Phosphatidylethanolamine) |
| CAS Number | 147867-65-0 |
| Molecular Formula | (C2H4O)x-C43H83NO10PNa (where x is the number of ethylene oxide units) |
| Molecular Weight | Varies based on PEG chain length (e.g., 2000 Da, 5000 Da) |
| Appearance | White to off-white solid or powder |
| Melting Point | 53-54°C (for mPEG-DSPE 2000) |
| Solubility | Soluble in chloroform, methanol, and water |
| Storage Conditions | -20°C, dry, avoid frequent freeze-thaw cycles |
| pKa | Not specified |
mPEG-DSPE: Additional Information
| Aspect | Details |
|---|---|
| Structure | mPEG-DSPE is an amphiphilic molecule with a hydrophobic DSPE part and a hydrophilic mPEG part. The DSPE part integrates into lipid bilayers, while the mPEG part forms a protective layer. |
| Applications | – Drug Delivery: Used in liposomes and lipid nanoparticles (LNPs) to enhance stability, prolong circulation time, and reduce immune recognition.<br>- Nanotechnology: Used for surface modification of nanoparticles to improve biocompatibility and prevent aggregation.<br>- Bioimaging: Used as a carrier for fluorescent probes in cell imaging. |
| Advantages | – Stealth Properties: The mPEG part reduces protein adsorption and immune recognition, prolonging circulation time.<br>- Biocompatibility: High biocompatibility reduces toxicity and immune reactions.<br>- Targeted Delivery: Can be modified with targeting ligands to deliver drugs to specific cells or tissues. |
| Synthesis | Prepared by esterification of mPEG with DSPE. |
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