Moxonidine HCl CAS NO.75438-58-3
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017216
CAS NO.75438-58-3
Purity 98+%
MDL NumberMFCD06795643
Molecular FormulaC9H12ClN5O.HCl
Molecular Weight278.1384
Melting point: 136~144°C
| Aspect | Details |
|---|---|
| Chemical Properties | – Molecular Formula: C9H13Cl2N5O<br>- Molecular Weight: 278.14 g/mol<br>- CAS Number: 75438-58-3<br>- Melting Point: 217-219°C |
| Mechanism of Action | – Moxonidine is a highly selective imidazoline I1-receptor agonist and a weaker α2-adrenergic receptor agonist.<br>- It acts centrally to reduce sympathetic nervous system activity, leading to decreased blood pressure. |
| Indications | – Treatment of mild to moderate essential hypertension.<br>- May be used when other antihypertensive agents (e.g., thiazides, beta-blockers, ACE inhibitors, calcium channel blockers) are not appropriate or have failed. |
| Pharmacokinetics | – Absorption: Well-absorbed orally.<br>- Metabolism: Approximately 10-20% metabolized to inactive metabolites.<br>- Excretion: Primarily excreted via the kidneys, with over 90% of the dose eliminated in the first 24 hours. |
| Adverse Effects | – Common: Dry mouth, fatigue, headache.<br>- Less common: Dizziness, insomnia, leg weakness. |
| Contraindications | – Sick sinus syndrome, sinus node and atrioventricular block (II-III degree), resting bradycardia (heart rate <50 beats/min), unstable angina, severe liver disease, progressive renal dysfunction, angioedema. |
| Special Considerations | – Monitor blood pressure and heart rate regularly.<br>- Use with caution in patients with renal impairment. |
| Storage Conditions | Store in a cool, dry place, protected from light and moisture |
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