Moxonidine HCl CAS NO.75438-58-3
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017216
CAS NO.75438-58-3
Purity 98+%
MDL NumberMFCD06795643
Molecular FormulaC9H12ClN5O.HCl
Molecular Weight278.1384
Melting point: 136~144°C
| Aspect | Details |
|---|---|
| Chemical Properties | – Molecular Formula: C9H13Cl2N5O<br>- Molecular Weight: 278.14 g/mol<br>- CAS Number: 75438-58-3<br>- Melting Point: 217-219°C |
| Mechanism of Action | – Moxonidine is a highly selective imidazoline I1-receptor agonist and a weaker α2-adrenergic receptor agonist.<br>- It acts centrally to reduce sympathetic nervous system activity, leading to decreased blood pressure. |
| Indications | – Treatment of mild to moderate essential hypertension.<br>- May be used when other antihypertensive agents (e.g., thiazides, beta-blockers, ACE inhibitors, calcium channel blockers) are not appropriate or have failed. |
| Pharmacokinetics | – Absorption: Well-absorbed orally.<br>- Metabolism: Approximately 10-20% metabolized to inactive metabolites.<br>- Excretion: Primarily excreted via the kidneys, with over 90% of the dose eliminated in the first 24 hours. |
| Adverse Effects | – Common: Dry mouth, fatigue, headache.<br>- Less common: Dizziness, insomnia, leg weakness. |
| Contraindications | – Sick sinus syndrome, sinus node and atrioventricular block (II-III degree), resting bradycardia (heart rate <50 beats/min), unstable angina, severe liver disease, progressive renal dysfunction, angioedema. |
| Special Considerations | – Monitor blood pressure and heart rate regularly.<br>- Use with caution in patients with renal impairment. |
| Storage Conditions | Store in a cool, dry place, protected from light and moisture |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
