Molsidomine CAS NO.25717-80-0
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Category：Active Pharmaceutical Ingredients MOQ:100KG Shipped directly from China
Introduction
Catalog ID80016998
CAS NO.25717-80-0
Purity 96%
MDL NumberMFCD00869301
EINEC247-207-4
Molecular FormulaC9H14N4O4
Molecular Weight242.2319
| Aspect | Details |
|---|---|
| Chemical Structure | – Molecular Formula: C₉H₁₄N₄O₄<br>- Molecular Weight: 238.23 g/mol |
| Mechanism of Action | – Molsidomine is metabolized in the liver to its active metabolite, SIN-1A, which releases nitric oxide (NO).<br>- NO increases cyclic GMP levels, leading to smooth muscle relaxation and vasodilation.<br>- It also inhibits platelet aggregation and has an indirect antiproliferative effect. |
| Clinical Uses | – Used for the treatment of ischemic heart disease, angina, chronic heart failure, and pulmonary hypertension.<br>- Effective in managing stable angina and improving coronary blood flow. |
| Pharmacokinetics | – Absorption: Peak plasma concentration occurs 1 to 2 hours after administration.<br>- Distribution: Volume of distribution is 98 L.<br>- Metabolism: Extensively metabolized in the liver to SIN-1A.<br>- Excretion: Metabolites are primarily excreted renally (90% to 95%). |
| Dosage Forms | – Available as tablets for oral administration. |
| Side Effects | – Common side effects include headache, dizziness, and gastrointestinal disturbances.<br>- Less common: Hypotension, flushing. |
| Special Precautions | – Use with caution in patients with hypotension or severe liver impairment.<br>- Monitor blood pressure and heart function during treatment. |
| Research Applications | – Investigated for its effects on reperfusion injury and platelet aggregation.<br>- Studied in clinical trials for its efficacy in acute myocardial infarction and unstable angina. |
| Synonyms | – Corvaton<br>- Molsidomine<br>- SIN-10 |
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