MLN8054
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID92545
CAS NO.869363-13-3 P
urity 97%
MDL NumberMFCD11840561
Molecular Formula C14H17NO4
Molecular Weight 263.289
Boiling point: 694.93°C at 760 mmHg
Flash point: 374.08°C
| Category | Content |
|---|---|
| Generic Name | MLN8054 |
| Chemical Formula | C25H15ClF2N4O2 |
| CAS Number | 869363-13-3 |
| Mechanism of Action | MLN8054 is a potent and selective inhibitor of Aurora A kinase, with an IC50 of 4 nM. It is >40-fold more selective for Aurora A compared to Aurora B. |
| Target Pathways | – Aurora A signaling pathway<br>- Cell cycle regulation |
| Biological Activity | – In Vitro: Exhibits antiproliferative activity against various human tumor cell lines, with IC50 values ranging from 0.11 μM to 1.43 μM.<br>- In Vivo: Demonstrates significant tumor growth inhibition in HCT-116 and PC-3 tumor xenograft models. |
| Applications | – Research: Used to study the role of Aurora A in cell division and cancer progression.<br>- Medicine: Investigated for potential use in treating various cancers, including colon cancer, breast cancer, and pancreatic cancer. |
| Physical Properties | – Appearance: White to yellow powder.<br>- Solubility: Soluble in DMSO (88 mg/mL), insoluble in ethanol and water.<br>- Storage: Powder (-20°C for 3 years); in solvent (-80°C for 1 year). |
| Safety | – Handle with care to avoid contact with skin and eyes.<br>- Store in a cool, dry place. |
| Developer | Takeda Pharmaceutical Co Ltd |
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