MLN8054
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID92545
CAS NO.869363-13-3 P
urity 97%
MDL NumberMFCD11840561
Molecular Formula C14H17NO4
Molecular Weight 263.289
Boiling point: 694.93°C at 760 mmHg
Flash point: 374.08°C
| Category | Content |
|---|---|
| Generic Name | MLN8054 |
| Chemical Formula | C25H15ClF2N4O2 |
| CAS Number | 869363-13-3 |
| Mechanism of Action | MLN8054 is a potent and selective inhibitor of Aurora A kinase, with an IC50 of 4 nM. It is >40-fold more selective for Aurora A compared to Aurora B. |
| Target Pathways | – Aurora A signaling pathway<br>- Cell cycle regulation |
| Biological Activity | – In Vitro: Exhibits antiproliferative activity against various human tumor cell lines, with IC50 values ranging from 0.11 μM to 1.43 μM.<br>- In Vivo: Demonstrates significant tumor growth inhibition in HCT-116 and PC-3 tumor xenograft models. |
| Applications | – Research: Used to study the role of Aurora A in cell division and cancer progression.<br>- Medicine: Investigated for potential use in treating various cancers, including colon cancer, breast cancer, and pancreatic cancer. |
| Physical Properties | – Appearance: White to yellow powder.<br>- Solubility: Soluble in DMSO (88 mg/mL), insoluble in ethanol and water.<br>- Storage: Powder (-20°C for 3 years); in solvent (-80°C for 1 year). |
| Safety | – Handle with care to avoid contact with skin and eyes.<br>- Store in a cool, dry place. |
| Developer | Takeda Pharmaceutical Co Ltd |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
