Minoxidil Sulphate
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80019720
CAS NO.83701-22-8
Purity 99%
MDL NumberMFCD06248907
Molecular FormulaC9H15N5O4S
Molecular Weight289.3115
Melting point: 177~178°C
| Category | Information |
|---|---|
| Chemical Properties | – Molecular Formula: C₉H₁₅N₅O₄S<br>- Molecular Weight: 289.31 g/mol |
| Physical Properties | – Appearance: White crystalline powder |
| Mechanism of Action | – Minoxidil Sulphate is the active metabolite of minoxidil, acting as an ATP-sensitive K⁺ channel opener.<br>- It promotes vasodilation and hair growth, though the exact mechanism for hair growth is still unclear. |
| Clinical Uses | – Hypertension: Used as a potent vasodilator to treat severe hypertension.<br>- Androgenetic Alopecia: Topical formulations are used to treat hair loss in both men and women. |
| Topical Formulations | – Investigated for treating scalp hair loss.<br>- Available in some regions, such as Brazil. |
| Stability | – Highly unstable in aqueous solutions and alcohol-containing solvents, with a half-life of 6 hours in aqueous solutions. |
| Storage Conditions | – Powder: Store at -20°C for up to 3 years.<br>- In solvent: Store at -80°C for up to 1 year. |
| Solubility | – Soluble in DMSO (57 mg/mL, 197.02 mM). |
| Side Effects | – Topical Use: Scalp irritation, dryness, itching, and hypertrichosis (excessive hair growth) in treated areas.<br>- Systemic Effects: When used orally, may cause edema, weight gain, tachycardia, and other cardiovascular effects. |
| Special Notes | – Higher molecular weight compared to minoxidil, potentially reducing scalp absorption.<br>- Efficacy for hair regrowth may be lower than minoxidil base due to instability and higher molecular weight. |
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