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CAS 3810 74 0

Title	Content
Introduction	Miconazole Nitrate is a widely used antifungal medication available in various forms such as creams, gels, powders, and suppositories. It is commonly known by brand names like Daktarin, Monistat, and Lotrimin.
Mechanism of Action	Miconazole Nitrate works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. This disrupts the integrity of the fungal cell membrane, leading to fungal cell death.
Medical Uses	– Skin Infections: Effective for treating ringworm, athlete’s foot, and jock itch.<br>- Vaginal Yeast Infections: Available as suppositories or creams for treating yeast infections.<br>- Nail Infections: Used for fungal infections of the nails.
Dosage Forms	– Topical Creams/Gels: Applied directly to the affected skin, typically twice daily.<br>- Suppositories: Used for vaginal infections, usually inserted once a day.<br>- Powders: Sprinkled on affected areas for conditions like athlete’s foot.
Common Side Effects	– Skin Irritation: Burning, itching, or redness at the application site.<br>- Vaginal Discomfort: Irritation, itching, or burning sensation during treatment.<br>- Systemic Effects: Rare but may include headache or nausea.
Serious Side Effects	– Allergic Reactions: Rash, swelling (especially of the face or throat), difficulty breathing.<br>- Severe Skin Reactions: Persistent irritation or worsening of symptoms.
Precautions	– Allergies: Inform your doctor if you are allergic to azole antifungals.<br>- Medical History: Disclose any history of diabetes, circulation problems, or liver/kidney issues.<br>- Pregnancy and Breastfeeding: Consult your doctor before use.
Storage Conditions	Store at room temperature, avoid freezing and protect from heat or open flame.

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