Metoclopramide
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID815729
CAS NO.364-62-5
Purity 98%
MDL NumberMFCD00211338
Molecular FormulaC14H22ClN3O2
Molecular Weight299.7964
Melting point: 146.5~148°C
| Category | Content |
|---|---|
| Generic Name | Metoclopramide |
| Brand Name | Reglan |
| Mechanism of Action | Metoclopramide is a dopamine receptor antagonist that blocks dopamine receptors in the brain and gastrointestinal tract. It increases gastric motility, accelerates gastric emptying, and reduces nausea and vomiting. |
| Indications | – Treatment of gastroesophageal reflux disease (GERD) when other medications fail.<br>- Management of diabetic gastroparesis.<br>- Control of nausea and vomiting in chemotherapy patients.<br>- Prophylaxis of nausea and vomiting in postoperative patients.<br>- Off-label use for acute migraine treatment. |
| Dosage Forms | Tablets, oral solution, injection forms. |
| Administration | – Taken orally 30 minutes before meals and at bedtime.<br>- For GERD: 10-15 mg four times daily.<br>- For gastroparesis: 10 mg four times daily.<br>- For chemotherapy-induced nausea: 1-2 mg/kg IV every 2-3 hours. |
| Common Side Effects | – Nausea, vomiting, diarrhea.<br>- Drowsiness, dizziness.<br>- Headache.<br>- Fatigue. |
| Serious Side Effects | – Extrapyramidal symptoms (e.g., muscle spasms, involuntary movements).<br>- Tardive dyskinesia (irreversible in some cases).<br>- Depression.<br>- Seizures.<br>- Hypertension.<br>- Cardiac arrhythmias. |
| Contraindications | – Hypersensitivity to metoclopramide.<br>- Gastrointestinal bleeding, obstruction, or perforation.<br>- Pheochromocytoma.<br>- Seizure disorders.<br>- Depression.<br>- Parkinson’s disease. |
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