Methylmagnesium chloride
Pharmaceutical Materials 2025-03-02
CAS Number: 676-58-4.
Molecular Formula: CH3MgCl.
Molecular Weight: 74.79 g/mol.
Appearance: Colorless to yellow or brownish liquid with a special pungent odor.
Usage: It is a widely used Grignard reagent in organic synthesis, particularly in the synthesis of drugs such as quinolone antibiotics.
| Attribute | Details |
|---|---|
| Chemical Name | Methylmagnesium Chloride |
| CAS Number | 14904-03-3 |
| Formula | CH3MgCl |
| Molecular Weight | 64.79 g/mol |
| Appearance | Colorless to light yellow transparent liquid (diethyl ether complex) or crystalline solid (tetrahydrofuran complex) |
| Solubility | Soluble in ether, tetrahydrofuran (THF), and other organic solvents |
| Density | Approximately 0.96 g/mL (diethyl ether complex) |
| Boiling Point | Decomposes before boiling (reactive and flammable) |
| Stability | Highly reactive; pyrophoric; reacts vigorously with water, oxygen, and acids |
| Preparation | Prepared by the reaction of magnesium metal with methane or halogenated methane compounds in the presence of a catalyst |
| Applications | Important reagent in organic synthesis; used as a Grignard reagent for the preparation of alkylmagnesium compounds; employed in the synthesis of alcohols, aldehydes, ketones, and other organic compounds |
| Safety Hazards | Highly flammable and reactive; may cause severe burns and ignite spontaneously if exposed to air or water; should be handled in a well-ventilated area with appropriate personal protective equipment; store under inert gas or dry conditions |
| Disposal | Dispose of according to local regulations; typically, treated as hazardous waste and disposed of in a controlled manner in approved facilities. |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
