Methyl 4-chloro-3-oxo-butanoate
Pharmaceutical Materials 2025-03-02
CAS Number: 32807-28-6
Molecular Formula: C5H7ClO3
Molecular Weight: 150.56 g/mol
Appearance: Colorless or slightly yellow liquid
Melting Point: 14-16°C
Boiling Point: 212-213°C
Use: Widely used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.
| Property | Details |
|---|---|
| Chemical Name | Methyl 4-chloro-3-oxo-butanoate |
| Other Names | 4-Chloroacetylacetic acid methyl ester; γ-Chloroacetoacetic acid methyl ester; Methyl 4-chloroacetoacetate |
| CAS Number | 598-55-0 |
| Molecular Formula | C5H7ClO3 |
| Molecular Weight | 150.56 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 190-192 ºC (lit.) |
| Density | 1.245 g/mL at 25 ºC (lit.) |
| Refractive Index | 1.442-1.444 (lit.) |
| Flash Point | 73 ºC |
| Solubility | Soluble in organic solvents such as ethanol, ether, and acetone; Slightly soluble in water |
| Stability | Stable under normal conditions; May decompose under heat or in the presence of strong acids or bases |
| Storage Conditions | Store in a cool, dry place, away from heat, sparks, and open flames; Keep container tightly closed and in a well-ventilated area |
| Usage | Used as an intermediate in the synthesis of pharmaceuticals, pesticides, and dyes; Important intermediate in the production of statin drugs, such as atorvastatin and simvastatin |
| Safety Information | May be harmful if swallowed or inhaled; Causes skin and eye irritation; May cause respiratory irritation; Keep away from sources of ignition; Store and handle with caution; Wear appropriate protective clothing and eye/face protection |
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