Pharmaceutical Materials

CAS Number: 59337-92-7

Molecular Formula: C6H5ClO4S2

Molecular Weight: 240.68 g/mol

Appearance: White to brown crystalline powder

Melting Point: 61-64°C

Usage: Used as a pharmaceutical intermediate.

 

Aspect	Details
Name	Methyl 3-Chlorosulfonylthiophene-2-carboxylate
Common Synonyms	3-(Chlorosulfonyl)thiophene-2-carboxylic acid methyl ester
CAS No.	137981-68-6
Molecular Formula	C₆H₅ClO₄S₂
Molecular Weight	252.69 g/mol
Physical Properties	Appearance: Pale yellow to light-brown crystalline solid Melting Point: Not explicitly stated but typically handled as a solid at room temperature Solubility: Soluble in organic solvents like DCM, DMF, and DMSO; sparingly soluble in water Density: Approximately 1.5-1.6 g/cm³ (estimated based on molecular structure)
Chemical Properties	Features a thiophene ring substituted with a chlorosulfonyl group (-SO₂Cl) at the 3-position and a methyl ester group (-COOCH₃) at the 2-position. The chlorosulfonyl group is highly reactive, enabling nucleophilic substitution and addition reactions, while the ester group can undergo hydrolysis or transesterification.
Applications	Used as a key intermediate in the synthesis of sulfonamide-based pharmaceuticals and agrochemicals Employed in the preparation of functional materials, such as polymers and liquid crystals
Safety Information	Handle with care due to the corrosive nature of the chlorosulfonyl group Store in a cool, dry, and well-ventilated area away from moisture and incompatible materials

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