Methyl 2-amino-3-nitrobenzoate
Pharmaceutical Materials 2025-03-02
CAS Number: 57113-91-4
Molecular Formula: C8H8N2O4
Molecular Weight: 196.16 g/mol
Appearance: White or off-white powder Melting Point: 97-98°C
Usage: Mainly used as an intermediate in the production of pharmaceuticals, especially for the synthesis of candesartan cilexetil.
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| Attribute | Details |
|---|---|
| Chemical Name | Methyl 2-Amino-3-Nitrobenzoate |
| Synonyms | Methyl 3-nitro-2-aminobenzoate; 2-Amino-3-nitrobenzoic acid methyl ester |
| CAS Number | 5337-97-9 |
| Molecular Formula | C8H8N2O4 |
| Molecular Weight | 196.16 g/mol |
| Appearance | Yellowish crystals or powder |
| Melting Point | 149-153 °C (literature); 150-152 °C (experimental) |
| Boiling Point | 315.4 °C at 760 mmHg |
| Density | 1.407 g/cm³ |
| Solubility | Soluble in organic solvents such as ethanol and ether; slightly soluble in water |
| Stability | Stable under normal conditions; incompatible with strong oxidizing agents and bases |
| Uses | Intermediate in the synthesis of dyes, pigments, and pharmaceuticals; used as a starting material for the preparation of heterocyclic compounds |
| Production Method | Prepared by esterification of 2-amino-3-nitrobenzoic acid with methanol using a sulfuric acid catalyst, followed by purification |
| Hazards | Irritating to skin, eyes, and respiratory system; may cause sensitization by skin contact; harmful if swallowed or inhaled; refer to the MSDS for detailed safety information |
| Safety Instructions | Handle with caution; wear appropriate protective clothing, gloves, and eye protection; avoid contact with skin, eyes, and ingestion; store in a cool, dry place away from incompatible substances and sources of ignition |
